Transferrin receptor expression by human bladder transitional cell carcinomas |
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| Authors: | G. J. Seymour M. D. Walsh M. F. Lavin G. Strutton Dr. R. A. Gardiner |
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| Affiliation: | (1) Department of Surgery, University of Queensland, St. Lucia, Brisbane, Australia;(2) Department of Social and Preventive Dentistry, University of Queensland, St. Lucia, Brisbane, Australia;(3) Department of Biochemistry, University of Queensland, St. Lucia, Brisbane, Australia;(4) Department of Surgery, Royal Brisbane Hospital, Clinical Sciences Building, 4029 Herston, Australia |
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| Abstract: | Summary The expression of transferrin receptors (TFR) by normal and neoplastic urothelial cells was studied in  control patients and in patients with transitional cell carcinoma of the bladder. These tumours were graded independently and consisted of 19 grade I, 30 grade II and 19 grade III lesions. TFRs were identified using a monoclonal antibody specific for TFR (OKT9) in an immunofluorescent or avidin/biotin-immunoperoxidase technique on fresh frozen sections. TFRs were not detected on normal urothelium. However, positive staining was found to increase with increasing pathological grade and stage of the tumours, ranging from 31.6% of grade I to 78.9% of grade III tumours and 51.2% of pTa (mucosa only lesions) to 87.5% of pT2/pT2+ (muscle invasion±deeper) primary urothelial malignancies. |
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| Keywords: | Transferrin receptors Human bladder carcinoma |
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