The value of immunohistochemical markers in the diagnosis of cervical neoplasia |
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| Authors: | R. E. FRAY Senior Registrar O. A. N. HUSAIN Consultant A. C. W. TO Senior Scientist K. C. WATTS Senior Scientist S. LADER Trials Organizer G. T. ROGERS Principal Biochemist J. TAYLOR-PAPADIMITRIOU Senior Scientist N. F. MORRIS Professor |
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| Affiliation: | Department of Obstetrics and Gynaecology, West London Hospital, London W6;Department of Cytology, Charing Cross and St Stephen's Hospital, Chelsea;Wellcome Diagnostics, Beckenham, Kent;Department of Medical Oncology, Charing Cross Hospital, London W6;Imperial Cancer Research Fund, London |
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| Abstract: | ![]()
Summary. This study was designed to determine whether immunohistochemical stains for tumour-associated markers may be useful in the detection and differential diagnosis of premalignant and malignant lesions of the cervix. The expression of four markers detected by monoclonal antibodies, human milk fat globule 1 and 2 (HMFG-1 and 2), Cal and anti-carcinoembryonic antigen (anti-CEA) on conventional histological sections of various cervical lesions has been investigated. None of these markers was specific for neoplastic lesions of the cervix and all four markers were expressed by metaplastic as well as neoplastic cells, and it was concluded that their application in the histopathological examination of the cervix is limited. |
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