| 基质金属蛋白酶-2和基质金属蛋白酶-9在前列腺癌组织中表达的免疫组织化学研究 |
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| 引用本文： | 曾汉青,肖亚军,陈勇. 基质金属蛋白酶-2和基质金属蛋白酶-9在前列腺癌组织中表达的免疫组织化学研究[J]. 临床泌尿外科杂志, 2002, 17(5): 235-236 |
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| 作者姓名： | 曾汉青 肖亚军 陈勇 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院泌尿外科,武汉,430022;武汉大学中南医院泌尿外科 |
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| 摘 要： | 目的：探讨基质金属蛋白酶－2（MMP－2）和基质金属蛋白酶－9（MMP－9）在胶列腺癌组织中的表达及其与前列腺癌侵袭的关系。方法：采用免疫组织化学方法检测前列腺癌组织及良性前列腺增生组织中MMP－2和MMP－9的表达。结果：前列腺癌组织中MMP－2和MMP－9的表达显著高于良性前列腺增生组织（P＜0．01）,前列腺癌组织中MMP－2,MMP－9的表达与侵袭程度呈正相关,结论：MMP－2和MMP－9是检测前列腺癌较好的分子标志,可用于前列腺癌的辅助诊断和预后判断。
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| 关 键 词： | 前列腺肿瘤 基质金属蛋白酶-2 基质金属蛋白酶-9 免疫组织化学 |
| 文章编号： | 1001-1420(2002)05-0235-02 |
| 修稿时间： | 2001-04-12 |
Immunohistochemical studies of the expression of matrix metall oproteinase-2 and metalloproteinase-9 in human prostate cancer |
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| ZENG Hanqing XIAO Yajun CHEN Yong. Immunohistochemical studies of the expression of matrix metall oproteinase-2 and metalloproteinase-9 in human prostate cancer[J]. Journal of Clinical Urology, 2002, 17(5): 235-236 |
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| Authors: | ZENG Hanqing XIAO Yajun CHEN Yong |
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| Affiliation: | ZENG Hanqing 1 XIAO Yajun 1 CHEN Yong 2 |
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| Abstract: | Purpose:To study the express of matrix metalloproteinase-2 and -9 in human prostate cancer.Methods:Matrix metalloproteinase-2 and -9 were detected by immunohistochemistry method in tissues of prostate cancer and BPH. Results:The matrix metalloproteinase-2 and -9 levels in prostate cancer were much higer than those in BPH, and the degree of cancer invasion positively correlated with the expression of the metalloproteinases. Conclusions:Matrix metalloproteinase-2 and -9 are pretty good molecular markers of prostate cancer which can be used to assist diagnosis and predict prognosis. |
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| Keywords: | Prostatic neoplasms Matrix metalloproteinase-2 Matrix metalloproteinase-9 Immunohistochemistry |
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