乳腺癌新辅助化疗后钙化与临床病理特征及预后的关系分析

目的 分析乳腺癌新辅助化疗后钙化与临床病理特征及预后的关系,以期指导患者后续治疗.方法 选择2020年1月至2021年9月本院收治的160例乳腺癌患者作为研究对象,入院后均行新辅助化疗,根据新辅助化疗后钙化状态的改变分为钙化减少组、钙化增加组、无变化组,比较三组的临床病理特征、无病生存期(DFS)、总生存期(OS).结...

Analysis of relationship between calcification and clinicopathological features,prognosis of breast cancer after neoadjuvant chemotherapy

Objective To analyze the relationship between calcification and clinicopathological features,prognosis of breast cancer after neoadjuvant chemotherapy,in order to guide subsequent treatment of patients.Methods A total of 160 patients with breast cancer admitted in our hospital from January 2020 to September 2021 were selected as the research objects.All patients received neoadjuvant chemotherapy after admission.According to the change of calcification state after neoadjuvant chemotherapy,the patients were divided into calcification reduction group,calcification increased group and non-change group.The clinicopathological features,disease-free survival(DFS)and overall survival(OS)among the three groups were compared.Results In 160 cases of breast cancer,48 cases were calcification reduction after neoadjuvant chemotherapy,32 cases were calcification increased,and remaining 80 cases were non-change.There were no significant differences in age,breast density,tumor stage,histological grade,histological type and TNM stage among the three groups(P>0.05);there were significant differences in lesion diameter,MP grade of chemotherapy reaction,pathological molecular classification,calcification distribution and calcification morphology among the three groups(P<0.05).The proportion of patients with lesion diameter>3 cm in the calcification increased group was 84.38%.The proportion of patients with MP grade of chemotherapy reaction was grade 3-4 in the calcification reduction group was 81.25%,and the proportion of patients with MP grade of chemotherapy reaction was grade 1-2 in the calcification increased group was 65.62%.The proportion of patients with PR positive in the calcification reduction group was 47.92%,and the proportion of patients with HER2 positive in the calcification increased group was 50.00%.The proportion of patients with calcification only in the mass in the calcification reduction group was 41.67%.The proportion of patients with calcification morphology of fine pleomorphism,thin line or thin line branching in the calcification reduction group was 75.00%.There were no significant differences in DFS and OS among the three groups(P>0.05);there were no significant differences in DFS and OS between the three groups(P>0.05).Conclusion The calcification state of breast cancer patients will change after neoadjuvant chemotherapy.This change is related to the lesion diameter,MP grade of chemotherapy reaction,pathological molecular classification,calcification distribution and calcification morphology and so on.The larger lesion diameter of breast cancer,pathological molecular classification is HER2 positive is more likely calcification increased.Calcification has no significant effect on the prognosis of patients.Whether it can be used as an efficacy evaluation index of neoadjuvant chemotherapy remains to be further studied.