银杏达莫注射液联合羟苯磺酸钙治疗糖尿病肾病的临床效果

目的 研究银杏达莫注射液联合羟苯磺酸钙治疗糖尿病肾病的临床效果,为临床治疗提供依据.方法 选取我院2020年1月至2021年1月收治的71例糖尿病肾病患者为研究对象,将其随机分为对照组(n=36)和研究组(n=35).对照组给予羟苯磺酸钙治疗,研究组在对照组基础上联合银杏达莫注射液进行治疗.比较两组的肾功能指标、血流动...

Clinical effect of ginkgo leaf extract and dipyridamole injection combined with calcium dobesilate in the treatment of diabetic nephropathy

Objective To study the clinical effect of ginkgo leaf extract and dipyridamole injection combined with calcium dobesilate in the treatment of diabetic nephropathy, so as to provide evidence for clinical treatment. Methods Seventy-one cases of diabetic nephropathy enrolled in our hospital from January 2020 to January 2021 were selected as the research subjects and randomly divided into control group(n=36) and study group(n=35). The control group was treated with calcium dobesilate, and the study group was treated with ginkgo leaf extract and dipyridamole injection on the basis of the control group. The indexes of renal function, hemodynamics, blood lipid, TCM syndrome score and quality of life were compared between the two groups. Results After treatment, the levels of 24 h urinary microalbumin, blood urea nitrogen and blood creatinine in the two groups were significantly lower than those before treatment, those in the study group were lower than the control group, and the differences were statistically significant(P <0.05). After treatment, the erythrocyte aggregation index, whole blood low shear viscosity and whole blood high shear viscosity in the two groups were significantly lower than those before treatment, those in the study group were lower than the control group, and the differences were statistically significant(P<0.05). After treatment, the blood flow velocity, triglyceride and low density lipoprotein levels in the study group were better than those in the control group, and the differences were statistically significant(P<0.05). After treatment, the TCM syndrome score in the two groups was significantly lower than that before treatment, that in the study group was lower than the control group, and the difference was statistically significant(P<0.05). After treatment, the DSQL scores and total score in the two groups were significantly lower than those before treatment, and those in the study group were lower than the control group(P<0.05). Conclusion Ginkgo leaf extract and dipyridamole injection combined with calcium dobesilate in the treatment of diabetic nephropathy can effectively improve the renal function, hemodynamic indexes and blood lipid indexes of patients, reduce the clinical symptoms and improve the quality of life.