黄芪多糖注射液对肺癌术后放化疗患者肝功能、脂糖代谢及免疫功能的影响

目的] 探讨黄芪多糖注射液对非小细胞肺癌(NSCLC)术后放化疗患者肝功能、脂糖代谢及免疫功能的影响.方法] NSCLC患者87例,分为观察组(n=45)与对照组(n=42),术后均予以放化疗综合治疗.观察组在此基础上应用黄芪多糖注射液,比较两组治疗前后谷丙转氨酶(ALT)、谷草转氨酶(AST)等肝功能指标、空腹血糖(FPG)、餐后2 h血糖(2hPG)、高密度脂蛋白胆固醇(HDL-C)等糖脂代谢指标及CD4+、CD8+T淋巴细胞亚群等免疫指标.结果] 两组治疗前各指标相比较差异均无显著性(P<0.05);治疗后两组ALT、AST均治疗前升高(P<0.05),且观察组治疗后的ALT、AST均低于对照组(P<0.05).治疗后观察组FPG、2hPG、HDL-C无明显变化(P<0.05),对照组FPG、2hPG、HDL-C高于治疗前及观察组治疗后(均P<0.05).治疗后两组CD8+均无明显变化(P<0.05),观察组CD4+高于治疗前及对照组治疗后(均P<0.05).结论] 黄芪多糖注射液可有效减轻肺癌术后放化疗患者的肝功能损伤,增强机体免疫,缓解化疗所引起的血糖、血脂升高情况,提高患者耐受性.

Effects of Astragalus Polysaccharide Injection on Liver Function,Lipid and Glucose Metabolism,and Immune System in Patients Undergoing Radiotherapy and Chemotherapy after Lung Cancer Surgery

Objective]To explore the effects of Astragalus polysaccharides injection on liver function,lipid and glucose metabolism,and immune function in patients undergoing radiotherapy and chemotherapy after lung cancer surgery.Methods]Eighty-seven patients with NSCLC were divided into the observation group (A group,n=45) and the control group (B group,n=42).Patients in the two groups were treated with the same radiotherapy and chemotherapy plan after surgery.In addition,patients in the A group were treated with Astragalus polysaccharides injection.Liver function indexes alanine transaminase (ALT),aspartate aminotransferase (AST)],glucose and lipid metabolism indexes fasting plasma glucose (FPG),postprandial 2h plasma glucose (2hPG),high density lipoprotein (HDL-C)]and immune indexes(CD4+,CD8+) were compared between the two groups before and after treatment.Results]Before treatment,there were no significant differences in all indexes between the two groups(P>0.05).After treatment,ALT and AST in the two groups were increased (P<0.05).However,those changes in the A group were lower than those in the B group(P<0.05).In the comparison of before and after treatment,there were no significant changes in levels of FPG,2hPG and HDL-C in the A group (P>0.05).On the other hand,levels of FPG,2hPG,and HDL-C in B group after treatment were higher than before treatment and the levels in the A group after treatment (all P<0.05).After treatment,there were no significant changes of CD8+ between the two groups (P>0.05).However,the CD4+ rate in the A group after treatment was higher than that before treatment and post-treatment in B group (all P<0.05).Conclusion]Astragalus polysaccharides injection can effectively reduce liver function damage,enhance immune function,relieve the elevation of blood glucose and blood lipids induced by chemotherapy and improve the tolerance of patients undergoing radiotherapy and chemotherapy after lung cancer surgery.