孤独症谱系障碍患儿维生素D水平及其与临床症状关系的研究

目的]了解孤独症谱系障碍(Autism Spectrum Disorders,ASD)患儿血清25羟维生素D25 hydroxyvitamin D,25(OH)D]水平及其与临床症状的关系,为儿童孤独症的病因及治疗提供线索和依据.方法]选择2014年6月至2016年6月于本院确诊的孤独症患儿60例作为观察组,选择同期在本院儿童保健科门诊体检正常的儿童60例作为对照组.采用酶联免疫吸附法(ELISA)检测两组儿童血清25(OH)D水平.根据儿童孤独症评定量表(Childhood Autism Rating Scale,CARS)评定孤独症患儿的疾病严重程度.比较两组间25(OH)D水平及其与CARS评分相关性,比较睡眠障碍及胃肠道紊乱发生率及其与25(OH)D水平的关系.结果]观察组25(OH)D水平明显低于对照组,但其与CARS评分无显著相关性.观察组睡眠障碍及胃肠功能紊乱的发生率明显高于对照组(P＜0.001),但两者发生率与25(OH)D水平无显著相关性.结论]观察组25(OH)D水平明显低于对照组,但其与ASD患儿疾病严重程度、睡眠障碍及胃肠功能紊乱发生率无明显相关性.

Study on the Relationship between Vitamin D and Clinical Symptoms in Children with Autism Spectrum Disorders

Objective]To investigate the serum 25-hydroxy vitamin D 25 (OH) D] levels in children with Autism Spectrum Disorders (ASDs) and the relationship with clinical symptoms so as to provide clues and basis for the etiology and treatment of autism.Methods]Sixty cases of children with autism diagnosed in Hunan Children's Hospital from June 2014 to June 2016 were selected as the observation group,and other sixty healthy children for normal physical examination were selected as control group in the same period of time.Serum levels of 25 (OH) D of the two groups were determined by enzyme-linked immunosorbent assay (ELISA).Childhood autism Rating Scale (CARS) was used to assess the severity of autism.The levels of 25 (OH) D and CARS score were compared between the two groups.The incidence of sleep disorders and gastrointestinal disorders and their relationship with the level of 25 (OH) D between the two groups were also compared.Results]The 25 (OH) D level in the observation group was significantly lower than that in the control group,but it was not significantly associated with the CARS score.The incidence of sleep disorders and gastrointestinal dysfunction in the observation group was significantly higher than those in the control group (P ＜0.001),but the incidence of two of them was not significantly associated with levels of 25 (OH) D.Conclusion]The 25 (OH) D level of the observation group is significantly lower than that of the control,but there is no significant correlation with the severity of ASD,sleep disturbance and gastrointestinal dysfunction.