丙泊酚与丙泊酚联合芬太尼在内镜逆行胰胆管造影术中麻醉效果比较

目的]比较分析丙泊酚、丙泊酚联合芬太尼在内镜逆行胰胆管造影术(ERCP)中的麻醉效果.方法]100例ERCP患者随机分为两组,各50例,观察组行丙泊酚联合芬太尼麻醉,对照组则单纯丙泊酚麻醉,比较两组麻醉效果及相关情况.结果]观察组麻醉优秀率96.00％(48/50)显著高于对照组76.00％ (38/50)(P＜0.05).观察组不同时间点心率(HR)、平均动脉压(MAP)、血氧饱和度(SpO2)相比较差异无显著性(P＞0.05);对照组术中(T2) HR、MAP较麻醉诱导前(T0)均显著下降(P＜0.05),且与观察组比较差异有显著性(P＜0.05).观察组意识消失时间、丙泊酚用量、意识恢复时间均明显少于对照组(P＜0.05).观察组呼吸抑制发生率4.00％显著低于对照组的16.00％(P＜0.05),而低血压、心动过缓发生率两组比较差异无显著性(P＞0.05).结论]丙泊酚联合芬太尼在ERCP术中麻醉效果明显优于丙泊酚单独应用,其能有效维持患者血流动力学稳定,显著减少丙泊酚用量,安全可行.

Comparison of the Anesthetic Effects between Simple Propofol and Propofol Combined with Fentanyl in Endoscopic Retrograde Cholangiopancreatography

Objective]To compare the anesthetic effects between propofol and propofol combined with fentanyl in endoscopic retrograde cholangiopancreatography (ERCP).Methods]One hundred patients undergoing ERCP were randomized into two groups with 50 cases in each group.The observation group received propofol combined with fentanyl anesthesia while the control group received simple propofol anesthesia.The anesthetic effects were compared between the two groups.Results]The excellent rate of anesthesia in the observation group (96.00 ％) was significantly higher than that in the control group (76.00％) (P ＜0.05).There were no significant differences in the hemodynamics (HR,MAP,SpO2) of the observation group at different time points (P ＞0.05).On the other hand,the HR and MAP of the control group during the operation (at T2) were significantly lower than before the induction of anesthesia (at T0) (P ＜0.05).The extinction time of consciousness and time of consciousness recovery of the observation group were significantly shorter than those of the control group,and dosage of propofol was significantly less (P ＜0.05).The incidence of respiratory depression in the observation group (4.00％) was significantly lower than that in the control group (16.00 ％) (P ＜0.05) while there were no significant differences in hypotension and bradycardia (P＞0.05).Conclusion]The anesthetic effect of propofol combined with fentanyl in ERCP was significantly better than that of propofol,and it can effectively maintain the stability of hemodynamics and reduce the dosage of propofol.