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| 血清Ⅰ型前胶原氨基端前肽、Ⅰ型前胶原羧基端前肽、Ⅰ型胶原羧基端肽在骨转移性癌诊断中的应用 | |
| 引用本文： | 王抒,张军宁,乔田奎. 血清Ⅰ型前胶原氨基端前肽、Ⅰ型前胶原羧基端前肽、Ⅰ型胶原羧基端肽在骨转移性癌诊断中的应用[J]. 中国临床医学, 2011, 18(4): 456-458 |
| 作者姓名： | 王抒 张军宁 乔田奎 |
| 作者单位： | 1. 复旦大学附属金山医院放疗科,上海,200540 2. 苏州大学附属第一医院放疗科,江苏苏州,215006 |
| 摘 要： | 目的：探讨血清Ⅰ型前胶原氨基端前肽（PINP）、Ⅰ型前胶原羧基端前肽（PICP）、Ⅰ型胶原羧基端肽（ICTP）在骨转移癌诊断中的临床价值。方法：将80例肿瘤患者分为骨转移组41例和无骨转移组（对照组）39例,采用Soloway分级标准,将骨转移组患者再分为A、B、C3个亚组,所有患者空腹抽取静脉血。分析血清PINP、PICP、ICTP与骨转移程度之间的相关性及其彼此之间的相关性。结果：骨转移癌患者血清PINP、PICP、ICTP水平较对照组均升高,其中PICP、ICTP水平与对照组有显著差异（P〈0.01）;PINP、PICP、ICTP水平在A、B、C3组均依次递增;血清PICP水平与骨转移灶数目相关性良好（P〈0.01）,ICTP、PINP水平与骨转移灶数目呈一定相关（P〈0.05）;血清ICTP水平与PINP水平呈中度相关。结论：检测血清PINP、PICP、ICTP水平都能反映骨转移患者的病情变化,以检测血清PICP、ICTP水平临床价值高;血清PICP水平与骨转移数目的相关性良好。 |
| 关 键 词： | Ⅰ型前胶原氨基端前肽（PINP） Ⅰ型前胶原羧基端前肽（PICP） Ⅰ型胶原羧基端肽（ICTP） 骨转移 癌 |
Diagnosic Clinical Value of Serum PINP,PICP and ICTP Contents in Cancer Patients with Bone Metastases |
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| WANG Shu,ZHANG Junning,QIAO Tiankui. Diagnosic Clinical Value of Serum PINP,PICP and ICTP Contents in Cancer Patients with Bone Metastases[J]. Chinese Journal Of Clinical Medicine, 2011, 18(4): 456-458 | |
| Authors: | WANG Shu ZHANG Junning QIAO Tiankui |
| Affiliation: | WANG Shu1 ZHANG Junning2 QIAO Tiankui1 1.Department of Radiotherapy,Jinshan Hospital,Fudan University,Shanghai 200540,China,2.the First Hospital Attached to Suzhou University in Jiangsu Province,Suzhou 215006 |
| Abstract: | Objective:To study the clinical value of determination of serum procollagen I N-terminal propeptide(PINP),procollagen I carboxy-terminal propeptide(PICP) and carboxyterminal telopeptide of type I collagen(ICTP) contents in cancer patients with bone metastases for diagnosis.Methods: Serum PINP,PICP and ICTP contents were measured in 41 patients with bone metastases and 39 controls without bone metastases.The patients with bone metastases consisted of Group A,Group B and Group C.The comparison of bone turnove... |
| Keywords: | Procollagen I N-terminal propeptide Procollagen I carboxy-terminal propeptide carboxyterminal telopeptide of type I collagen Bone metastases Cancer |
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