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| 哈萨克族心力衰竭患者血浆和肽素、N端前体脑钠肽水平的变化及临床意义 | |
| 引用本文： | 王忠,张俣,王丽,毛宏伟,古丽巴哈,沙庆勇,霍昱吉,陈少泽,翟志红. 哈萨克族心力衰竭患者血浆和肽素、N端前体脑钠肽水平的变化及临床意义[J]. 临床心血管病杂志, 2011, 27(12) |
| 作者姓名： | 王忠 张俣 王丽 毛宏伟 古丽巴哈 沙庆勇 霍昱吉 陈少泽 翟志红 |
| 作者单位： | 1. 新疆石河子大学医学院第一附属医院心内二科,新疆石河子,832008 2. 新疆石河子大学医学院 3. 新疆伊犁州友谊医院心内科 |
| 摘 要： | 目的:探讨哈萨克族心力衰竭(心衰)患者血浆和肽素(Copeptin)、N端前体脑钠肽(NT-proBNP)水平的变化及临床意义。方法:使用酶联免疫吸附测定法(ELISA)测定90例哈族心衰患者(心衰组)和30例同期住院哈族无心功能不全患者(对照组)的血浆Copeptin、NT-proBNP水平,超声心动图测量左房内径(LAD)、左室舒张末内径(LVEDD)、左室射血分数(LVEF)、左室短轴缩短率(FS)。结果:哈族心衰患者血浆Copeptin、NT-proBNP显著高于对照组,且随NYHA心功能分级的升高而升高,各组间差异具有统计学意义(P<0.01)。心衰患者Copeption、NT-proBNP具有相关性(r=0.692,P<0.01)。单因素分析显示,Copeption、NT-proBNP与LAD、LVEDD呈正相关(均P<0.01),与LVEF、FS呈负相关(均P<0.01)。在心衰组,分别将年龄、性别、NY-HA分级、超声心动图所测LAD、LVEDD、LVEF、EF、FS共8个因素行多元逐步回归分析,结果只有NYHA和LVEF是Copeptin、NT-proBNP的独立相关因素。结论:哈族心衰患者... |
| 关 键 词： | 心力衰竭 和肽素 N端前体脑钠肽 哈萨克族 |
Changes and clinical significance of copeptin and NT-proBNP levels in Kazakhs patients with heart failure |
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| WANG Zhong,ZHANG Yu,WANG Li,MAO Hongwei,GU LI Baha,SHA Qingyong,HUO Yuji,CHEN Shaozhe,ZHAI Zhihong. Changes and clinical significance of copeptin and NT-proBNP levels in Kazakhs patients with heart failure[J]. Journal of Clinical Cardiology, 2011, 27(12) | |
| Authors: | WANG Zhong ZHANG Yu WANG Li MAO Hongwei GU LI Baha SHA Qingyong HUO Yuji CHEN Shaozhe ZHAI Zhihong |
| Affiliation: | WANG Zhong1 ZHANG Yu2 WANG Li1 MAO Hongwei3 GU LI Baha3 SHA Qingyong3 HUO Yuji2 CHEN Shaozhe1 ZHAI Zhihong1(1Department of Cardiology,the First Affiliated Hospital,Medical College of Shihezi University,Shihezi 832008,China,2Shihezi University Medical School,3Department of Cardiology,the Friendship Hospital of Yili) |
| Abstract: | Objective:To explore the change and significance of copeptin and NT-proBNP in Kazakhs patients with heart failure(HF).Method:The 90 Kazakhs patients with heart failure were analyzed as HF group and 30 patients without heart failure were served as control group.Every subject's plasma copeptin and NT-proBNP were detected by ELISA.The parameters of left atrial diameter(LAD),left ventricle end-diastolic diameter(LVEDD),left ventricle ejection fraction(LVEF),fraction shortening(FS) were detected with echocardiog... |
| Keywords: | copeptin NT-proBNP heart failure Kazakhs |
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