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| 基因多态性与激素性股骨头坏死遗传易感性及临床表型的关联 | |
| 引用本文： | 韦标方. 基因多态性与激素性股骨头坏死遗传易感性及临床表型的关联[J]. 山东医学高等专科学校学报, 2011, 0(5): 321-325 |
| 作者姓名： | 韦标方 |
| 作者单位： | 临沂市人民医院; |
| 基金项目： | 山东省科技发展公关计划项目(No.2010GWZ20221) |
| 摘 要： | 目的探讨单核苷酸多态性与激素性股骨头坏死（SONFH）及临床表型的关联。方法将134例使用激素治疗的患者依据是否发生股骨头坏死（ONFH）分为实验组（63例）和对照组（71例）,测定两组Factor V基因G1691A,GR基因JST006606、JST032069,CBP基因JST103922,ApoB基因C7623T、G12619A,CYP1A2基因T5347C、G2964A、C733A及CYP2C19基因G681A共10个位点的基因多态性,分析它们的基因型与等位基因频率的分布,同时检测两组的临床表型,包括实验室指标：血脂五项、骨钙素、血栓素B2（TXB2）、6-酮-前列腺素与基因型及ONFH之间的关系。结果 ApoB C7623T位点TT基因型和T等位基因出现的频率在实验组中明显高于对照组（P〈0.05）;Factor V基因G1691A、CYP1A2基因G2964A位点未检测出多态性。其余位点的基因多态性两组之间总体分布差异没有统计学意义。结论 CYP1A2G2964A与ApoB C7623T的基因多态性可能与SONFH的遗传易感性有关。CYP1A2G2964A与ApoB C7623T的基因多态性的协同作用与SONFH相关联。 |
| 关 键 词： | 激素性股骨头坏死 基因型 单核苷酸 |
RELATIONSHIP BETWEEN GENE POLYMORPHISMS AND SYNDROME TYPES IN STEROID-INDUCED FEMORAL HEAD OSTEONECROSIS |
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| WEI Biao-fang. RELATIONSHIP BETWEEN GENE POLYMORPHISMS AND SYNDROME TYPES IN STEROID-INDUCED FEMORAL HEAD OSTEONECROSIS[J]. Journal of Shandong Medical College, 2011, 0(5): 321-325 | |
| Authors: | WEI Biao-fang |
| Affiliation: | WEI Biao-fang(Linyi City People's Hospital,Linyi,China 276003) |
| Abstract: | Objective To investigate the relationship between Mononucleotide,polymorphisms(SNPs) and syndromes types in steroid-induced femoral head osteonecrosis(ONFH).Methods The genotypes of Factor V G1691A,GRJST006606,JST032069,CBPJST103922,ApoB C7623T,G12619A,CYP1A2T5347C,G2964A,C733A and CYP2C19 G681A sites were determined in 63cases with ONFH by consecutive steroid therapy and 71 cases without ONFH.The genotypes and alleles frequency distribution,and the relationship between the SNPs and syndromes were analyzed.... |
| Keywords: | Steroid-induced osteonecrosis of the femoral head Genotype Mononucleotid |
| 本文献已被 CNKI 维普 等数据库收录！ | |