Schwannian crystalline-like inclusions bodies (Fardeau-Engel bodies) revisited in peripheral neuropathies |
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Authors: | Vital Claude Bouillot Sandrine Canron Marie-Hélène Vital Anne |
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Institution: |
a Neuropathology Department, Victor Segalen University, Bordeaux, France. |
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Abstract: | In 1969, Fardeau and Engel described polygonal organelles containing crystalline-like structures located in the Schwann cell cytoplasm of unmyelinated fibers. Such inclusions were reported in various conditions, mainly with axonal lesions. They were also reported in a few cases of peripheral neuropathy associated with primary mitochondriopathy. Although they are surrounded by a double membrane, their mitochondrial origin is not definitely proven. Their significance remains obscure but they deserve to be better known as Fardeau-Engel bodies, so as not to be mistaken with mitochondrial crystalline inclusions, which are frequently observed in patients with ragged-red fibers in muscle. |
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Keywords: | Axonopathy Crystalline Inclusions Filaments Mitochondria Peripheral Neuropathy Schwann Cell |
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