Methylbromide: carcinogenic effects in the rat forestomach |
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| Authors: | L H Danse F L van Velsen C A van der Heijden |
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| Affiliation: | 1. Laboratory for Pathology, National Institute of Public Health, Bilthoven, The Netherlands;2. Laboratory for General Toxicology, National Institute of Public Health, Bilthoven, The Netherlands;3. Laboratory for Carcinogenesis and Mutagenesis, National Institute of Public Health, Bilthoven, The Netherlands |
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| Abstract: | Methylbromide (MB) administered by oral gavage as a solution in arachis oil was carcinogenic to rats in a 90-day experiment. In 13 of 20 animals of the highest dose group, 50 mg MB/kg body wt squamous cell carcinomas of the forestomach developed. All animals of this group showed a marked diffuse hyperplasia of the epithelium of the forestomach. A less pronounced hyperplasia was observed in high and lower incidence with respectively 10 and 2 mg MB/kg body wt. The lowest dose, 0.4 mg MB/kg body wt was without effects. |
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