Neuronal growth factors produced by adult peripheral nerve after injury |
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| Authors: | Anthony J. Windebank Joseph F. Poduslo |
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| Affiliation: | 1. Neurosurgery Research Group (NRG), Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran;2. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran;3. Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran;4. Department of Neurological Surgery, Pauline Braathen Neurological Center, Cleveland Clinic Florida, Weston, Florida, USA;5. Department of Neurological Surgery and Rosa Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio, USA;6. Department of Neurosurgery, Cleveland Clinic, Abu Dhabi, UAE;1. Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan;2. Department of Hand Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan;3. Department of Orthopedic Surgery, Anjo Kosei Hospital, Konan, Japan |
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| Abstract: | Dorsal root ganglion neurons from embryonic rats, co-cultured with endoneurial explants from transected, adult rat sciatic nerve, extended neurites in the absence of exogenous nerve growth factor (NGF). The effect was seen with endoneurial explants from normal adult sciatic nerves or from nerves which had been permanently transected up to 51 days prior to explantation. The rate of outgrowth decreased at 5 and 7 days and reached a minimum at 14 days after transection. A second phase of increased neurite-promoting activity appeared in 28-, 35-, 41- and 51-day posttransection tissue. The early phase, but not the late phase, was partially inhibited by antisera to NGF. |
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| Keywords: | Nerve growth factor Trophic factor Neurite-promoting factor Regeneration Peripheral nerve Schwann cell |
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