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脑毒清颗粒对脑缺血再灌注损伤大鼠SOD、MDA及hs-CRP含量的影响
引用本文:王巍,;曲颖,;贾维刚,;王加志. 脑毒清颗粒对脑缺血再灌注损伤大鼠SOD、MDA及hs-CRP含量的影响[J]. 中国中医急症, 2014, 0(9): 1605-1606
作者姓名:王巍,  曲颖,  贾维刚,  王加志
作者单位:[1]黑龙江省中医药科学院,黑龙江哈尔滨150001; [2]黑龙江省医院,黑龙江哈尔滨150001; [3]黑龙江中医药大学佳木斯学院,黑龙江佳木斯154000
基金项目:黑龙江省哈尔滨市青年科技创新人才研究专项资金项目(2010RFQYS084)
摘    要:目的 观察脑毒清颗粒对脑缺血再灌注损伤大鼠血清超氧化物歧化酶(SOD)、丙二醛(MDA)和超敏C反应蛋白(hs-CRP)含量的影响,探讨脑毒清颗粒对脑缺血再灌注损伤治疗的作用机制.方法 应用线栓法复制脑缺血再灌注损伤大鼠模型(MCAO),2h后抽取线栓对大鼠进行脑缺血再灌注,进行神经功能缺损程度评分,分别于12、24、48h 3个时间点观察大鼠血清SOD、MDA、hs-CRP含量的变化.结果 与模型组比较,脑毒清组大鼠神经功能缺损评分明显下降,大鼠血清SOD含量增多,MDA含量减少,hs-CRP含量减少.结论 脑毒清颗粒具有明显改善大鼠脑缺血再灌注损伤的作用,其机制与大鼠血清SOD、MDA及hs-CRP变化有关.

关 键 词:脑毒清颗粒  脑缺血再灌注损伤  超氧化物歧化酶  丙二醛  超敏C反应蛋白

Effect of Naoduqing Granules on SOD,MDA and hs-CRP Contents in Model Rats with Cerebral Ischemia-Reperfusion Injury
Affiliation:WANG Wei,QU Yin,JIA Weigang,et al.( 1 Heilongjiang Academy of Chinese Medical Sciences,Heilongjiang,Harbin 150001,China;2 Heilongjiang Provincial Hospital,Heilongjiang,Harbin 150001, China)
Abstract:Objective: To observe the effect and mechanism of Naoduqing Granules on SOD,MDA and hs-CRP contents of cerebral ischemia-reperfusion injury rats model. Methods: Animal model of focal cerebral ischemia was established by using suture method in mature SD rats. Neurological severity scores as well as the activity of MDA, SOD, hs-CRP in brain tissue of cerebral ischemia after 12,24, and 48 hours were detected. Results: Com- pared with model group,level of SOD was increased and level of MDA and hs-CRP were decreased with signifi- cant statistical differences. Conclusion: Naoduqing Granules has obvious ameliorating effect on rats with focal cerebral ischemia,which is caused by reduction of SOD, MDA and hs-CRP contents.
Keywords:Naoduqing Granules  Cerebral ischemia-reperfusion injury  SOD  MDA  hs-CRP
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