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Invited review: Frontotemporal dementia caused by microtubule‐associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging |
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| Authors: | Bernardino Ghetti Adrian L. Oblak Bradley F. Boeve Keith A. Johnson Bradford C. Dickerson Michel Goedert |
| Affiliation: | 1. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA;2. Department of Neurology, Mayo Clinic, Rochester, USA;3. Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, USA;4. Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA;5. Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK |
| Abstract: | Hereditary frontotemporal dementia associated with mutations in the microtubule‐associated protein tau gene (MAPT) is a protean disorder. Three neuropathologic subtypes can be recognized, based on the presence of inclusions made of tau isoforms with three and four repeats, predominantly three repeats and mostly four repeats. This is relevant for establishing a correlation between structural magnetic resonance imaging and positron emission tomography using tracers specific for aggregated tau. Longitudinal studies will be essential to determine the evolution of anatomical alterations from the asymptomatic stage to the various phases of disease following the onset of symptoms. |
| Keywords: | FTDP‐17 MAPT tau aggregation neurofibrillary tangle Pick body tau [F18]‐T807 |