食管癌危险因素的Meta分析

目的 对食管癌与其危险因素的关联性进行Meta分析。方法 应用Meta分析方法对国内有关食管癌危险因素的22个研究结果进行定量综合分析，用随机效应模型计算合并比值比(OR)及其95％可信区间(95％CI)。结果 吸烟、饮酒、快食、烫食、嗜淹菜、食管癌家族史、不良心理因素、嗜咸食的合并OR分别为2．08(95％CI：1．66-2．61)，1．51(1．25-1．81)，2．38(1．70-3．34)，2．11(1．67-2.66)，2．11(1．68-2．66)，3．09(2．37-4．03)，2．90(1．84-4．58)，1．30(0．96-1．77)。结论 吸烟、饮酒、快食、烫食、嗜淹菜、食管癌家族史、不良心理因素为食管癌的危险因素，嗜咸食与食管癌的关系尚不能确定。

Meta-analysis on risk factors of esophageal cancer

Objective To elvaluate the relation between the risk of esophageal cancer and its risk factors by means of meta-analysis.Methods 22 results on the risk factors of esophageal cancer were analysed by Meta-analysis.Random effect model is selected to calculate the pooled odds ratio (OR) and its corresponding 95% confidence interval (95%CI).Results The pooled odds ratioes for smoking,alcohol drinking,quick eating,over-hot diet,frequency intake of pickled vegetables,family history of esophageal cancer,unhealthy psychological factor and being fond of salty food were 2.08(95%CI:1 66-2 61),1.51(1.25-1.81),2.38(1.70-3.34),2.11(1.67-2.66),2.11(1.68-2.66),3.09(2.37-4.03),2.90(1.84-4.58).1.30(0.96-1.77),respectively.Conclusion Smoking, alcohol drinking,quick eating,over-hot diet,frequency intake of pickled vegetables,family history of esophageeal cancer and unhealthy psychological factor can increase the risk of esophageal cancer,but the effect of being fond of salty food on the esophageal cancer should be studied further.Comprehensive measures pertinent to the above mentioned risk factors should be taken to prevent and treat esophageal cancer.