308nm准分子激光联合胸腺肽治疗成人头面部白癜风临床观察

目的:探讨口服胸腺肽联合308nm准分子激光治疗白癜风的疗效及安全性。方法:85例患者随机分成两组。实验组44例,308nm准分子激光(2次/周)联合胸腺肽(10mg 2/日)治疗;对照组41例,单纯予308nm准分子激光治疗(2次/周),两组疗程25次。于治疗25次3天后进行疗效评价。结果:治疗结束后,实验组有效率为95.45%(42/44),对照组为87.8%(36/41),显效率实验组为72.73%(32/44),对照组为51.22%(21/41),两组间显效率有显著性差异(χ2=4.182,P=0.041),但有效率差异不显著(χ2=3.316,P=0.375)。对两组各30例患者随访6个月,实验组患者所有治疗皮损均维持稳定或持续好转,而对照组有2例皮损出现复发。结论:308nm准分子激光治疗白癜风疗效高、副作用少,联合口服胸腺肽可显著提高其疗效并减少复发。

Clinical study of combined 308 nm excimer laser and oral thymopeptides for the treatment of adult vitiligo involving the head and face

Objective We sought to assess the efficacy and safety of combined 308nm excimer laser and oral thymopeptides in the treatment of adult vitiligo involving the head and face.Methods 85 patients with vitiligo were randomly divided into experimental group(n=44) treated with 308nm excimer laser(biw) and thymopeptides(10mg bid),and control group(n=41) treated with simple 308nm excimer laser.Patients were treated for at least 25 times.Clinical responses were documented during clinic visits,and by pre-treatment and post-treatment photography.Results While the study completed,repigmentation was observed in 95.45%(42/44) of experimental group lesions and in 87.8%(36/41) of control group lesions.Significant improvement(a repigmentation rate of 50% or more) was obtained in 72.73%(32/44) of experimental group lesions and 51.22%(21/41) of control group lesions.Within the 6 following months,of 30 patients in every group,the treated lesions of experimental group were remained stably or got better continued,but 2 lesions of control group recurred.Conclusions The 308nm excimer laser was safe and effective in treatment of adult vitiligo involving the head and face.Combination treatment of oral thymopeptides could improve the efficacy significantly and prevent from recurrence.