胡蔓藤中非生物碱类化学成分的分离与鉴定

目的为进一步开发利用胡蔓藤(Gelsemium elegansBenth.)中非生物碱类化学成分提供依据。方法采用HPD-800大孔吸附树脂色谱、硅胶柱色谱和ODS中压柱色谱分离,采用葡聚糖凝胶LH-20柱色谱及制备液相纯化,根据理化性质和波谱数据鉴定结构。结果分离鉴定了7个非生物碱类化合物,分别为东莨菪内酯(scopoletin,1)、咖啡酸乙酯(caffeic acid ethyl ester,2)、肉桂酸(cin-namic acid,3)、水杨酸(salicylic acid,4)、香草酸(vanillic acid,5)、白藜芦醇(resveratrol,6)、正三十六烷醇(hexatriacontan-1-ol,7)。结论化合物2~4、6为首次从胡蔓藤属植物中分离得到。

Isolation and identification of the non-alkaloid constituents from Gelsemium elegans Benth.

Objective To investigate the non-alkaloid constituents from Gelsemium elegans Benth. Methods Solvent extraction and column chromatography were used to isolate the non-alkaloid constituents, and physicochemical properties and spectroscopic analysis were employed for the determination of the structures. Result Seven compounds were isolated, and their structures were identified as scopoletin(1)，caffeic acid ethyl ester(2)，cinnamic acid(3)，salicylic acid(4)，vanillic acid(5)，resveratrol(6) and hexatriacontan-1-ol(7). Conclusion Compounds 2-4 and 6 are obtained from this genus for the first time.