Russel bodies in the duodenal mucosa in ulcer disease]

A total of 103 specimens of the duodenum mucosa incised during the resection of the stomach in different variants of the course of peptic ulcer were studied. It was shown that Russell's bodies (RB) in the mucosa's layer proper were formed by cellular elements analogous to immunoglobulinocytes of the lymph nodes and spleen of the laboratory animals which had been subjected to an experimental stimulation of immunogenesis. Peculiar patterns of contacts of RB with the mast cells and possible significance of these contacts are discussed. On the basis of the data obtained the conclusion was drawn that elimination of the RB substrate in the duodenum mucosa was realized in two directions: a) centripetal by penetration of the substrate into the lymphatic and blood vessels; and b) centrifugal, by its evacuation into the lumen of the alimentary canal.