低氧诱导因子在生物医学中的作用

氧平衡在生物个体的生长和发育过程中具有重要的作用.细胞和组织为适应低氧调节转录子诱导多种基因参与到血管形成、铁代谢、葡萄精代谢和细胞的增殖及存活,而回应这些反应的要素因子是低氧诱导因子-1(hypoxia inducible factor-1,HIF-1).不断发展的生理学相关基因通过新的机制来降低细胞内氧浓度,上调感应和信号转导以触发HIF的低氧诱导转录活性.该途径最重要的是存在于所有的细胞和所有的真核生物中.现就HIF在生物医学中的作用作一综述.

The biomedical role of hypoxia inducible factor

Oxygen homeostasis is an important role in development of organism.Adaptation to low oxygen tension(hypoxia) in cells and tissues leads to the transcfptional induction of a series of genes that participate in angiogenesis,iron metabolism,glucose metabolism,and cell proliferation/survival.The primary factor mediating this response is the hypoxia.inducible factor-1(HIF-1).A growing number of physiologically relevant genes are up-regulated by falling intracellular oxygen tension for oxygen sensing and signaling that triggers the activation of the hypoxia-inducible transcription factor HIF-1.The importance of this pathway is suggested by its presence in virtually all cells and in all higher eukaryotes.In this review,we discuss the role of HIF-1 in hypoxia/ischemia disease.