Psychological impact of comprehensive tumor genomic profiling results for advanced cancer patients |
| |
| Institution: | 1. Psycho-Oncology Co-operative Research Group (PoCoG), Level 6 (North) Lifehouse (C36Z), School of Psychology, University of Sydney, Sydney 2006 Australia;2. School of Public Health, University of Sydney, 2006 Sydney, Australia;3. Cancer Theme, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia;4. St Vincent’s Clinical School, University of NSW, Sydney, Australia;5. School of Psychology, University of Sydney, Sydney 2006, Australia;6. Psychosocial Research Group, Prince of Wales Clinical School, University of NSW, Sydney 2052, Australia;7. Dept of Medical Oncology, Prince of Wales Hospital, 320-346 Barker St, Randwick, NSW 2031, Australia;8. Newborn Screening, Ethics and Disability Studies, RTI International, Washington, DC, USA;1. Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Public Health, Charité – Universitätsmedizin Berlin, Berlin, Germany;2. University of Education Freiburg, Department of Public Health and Health Education, Germany;3. Beuth University of Applied Sciences, Berlin, Germany;4. Institute of Social Medicine and Epidemiology, Brandenburg Medical School Theodor Fontane, Brandenburg an der Havel, Germany;1. Maastricht University, Department of Family Medicine, Care and Public Health Research Institute, Faculty of Health, Medicine and Life Sciences, Maastricht, The Netherlands;2. Maastricht University, Department of Educational Development and Research, School of Health Professions Education, Faculty of Health, Medicine and Life Sciences, Maastricht, The Netherlands;3. RCSI University of Medicine and Health Sciences, Health Professions Education Centre, Dublin, Ireland;1. University of Newcastle, Department of Rural Health, Tamworth, NSW 2340, Australia;2. Hunter New England Local Health District, Tamworth, NSW 2340, Australia;3. Rheumatology Practice, Tamworth, NSW 2340, Australia;1. Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium;2. Department of Palliative Care, University Hospitals Leuven, Belgium;3. LUCAS KU Leuven Centre for Care Research & Consultancy, Leuven, Belgium;4. Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium;5. Department of Oncology, KU Leuven, Leuven, Belgium;1. University of Kansas School of Medicine, Department of Population Health, Kansas City, KS USA;2. University of Kansas School of Nursing, Kansas City, KS USA;1. Ingham Institute for Applied Medical Research, Liverpool, NSW 2170, Australia;2. South West Sydney Clinical Campuses, UNSW Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia;3. South Western Sydney Local Health District, NSW, Australia;4. Illawarra Shoalhaven Local Health District, NSW, Australia |
| |
| Abstract: | ObjectiveComprehensive tumor genomic profiling (CTGP) is increasingly used to personalize treatments, providing hope, but potentially disappointment, for patients. We explored psychological outcomes in patients with advanced, incurable cancer, after receiving CTGP results.MethodsParticipants with advanced, incurable cancer (n = 560, mean age 56, 43% university educated) in this longitudinal substudy of the Molecular Screening and Therapeutics Program (MoST), completed questionnaires before and after receiving CGP results. MoST participants, recruited from Australian oncology clinics, undergo CTGP, and if there are actionable findings, are offered treatment in a related therapeutic trial if available.ResultsPatients who received actionable results, (n = 356, 64%) had lower gene-related distress (MICRA) (p < 0.001) and Impact of Events scores (p = 0.039) than patients with non-actionable results. Those with actionable results offered ensured access to tailored treatment (n = 151) reported lower anxiety (p = 0.002) and depressive symptoms (p = 0.01) and greater hope (p = 0.002) than those not offered. Positive attitudes towards uncertainty and higher self-efficacy for coping with results were associated with lower psychological distress and uncertainty, and higher hope and satisfaction with the decision to have CTGP (ps=0.001–0.047). Those with higher knowledge reported greater anxiety (p = 0.034).ConclusionReceiving a non-actionable CTGP result, or an actionable result without ensured access to treatment, may cause increased distress in advanced cancer patients. Coping style was also associated with distress.Practice implicationsPre-testing assessment and counseling addressing attitudes toward uncertainty and self-efficacy, and post-CTGP result support for patients receiving a non-actionable result or who receive an actionable results without ensured access to treatment, may benefit patients. |
| |
| Keywords: | Psychological outcomes Genomics Comprehensive tumor genomic profiling |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
