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| CRF01-AE基因亚型毒株在HIV传播及流行中的作用 | |
| 引用本文： | 孙显光,邢辉,李志坚,何翔,张信辉,申莉梅. CRF01-AE基因亚型毒株在HIV传播及流行中的作用[J]. 中国皮肤性病学杂志, 2011, 25(9) |
| 作者姓名： | 孙显光 邢辉 李志坚 何翔 张信辉 申莉梅 |
| 作者单位： | 1. 贵州省CDC艾滋病性病皮肤病防治研究所艾滋病二科,贵州贵阳,550002 2. 中国CDC艾滋病预防控制中心病免室,北京,102206 |
| 基金项目： | 贵州省"十一五"重点攻关社会发展资金项目 |
| 摘 要： | 目的研究HIV-1CRF01-AE亚型毒株与HIV传播及流行的关系,为预防控制艾滋病提供科学依据。方法分三个时段检测贵州省多地区190份HIV-1毒株样本,用套式PCR扩增其Env基因和测序分析,将实验结果与贵州省艾滋病流行现状进行相关分析。结果检出B,B',E,C亚型及CRF07-BC,CRF08-BC和CRF01-AE三种新的流行性重组亚型毒株,流行性重组亚型毒株是造成贵州省艾滋病流行的因素之一,其中CRF01-AE毒株与性传播、16～50岁年龄段高度相关。结论 CRF01-AE亚型毒株是贵州省艾滋病传播与流行的主要亚型毒株;16～50岁年龄段是CRF01-AE亚型毒株通过性传播艾滋病的主体人群;CRF01-AE亚型毒株引起的艾滋病流行,具有传播范围广、流行时间长、控制难度大等特点。 |
| 关 键 词： | 基因亚型毒株 性传播 艾滋病流行 |
Effect of HIV-I CRF01-AE in HIV Transmission and Epidemic |
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| SUN Xian-guang,XING Hui,LI Zhi-jian,HE Xiang,ZHANG Xin-hui,SHEN Li-mei. Effect of HIV-I CRF01-AE in HIV Transmission and Epidemic[J]. The Chinese Journal of Dermatovenereology, 2011, 25(9) | |
| Authors: | SUN Xian-guang XING Hui LI Zhi-jian HE Xiang ZHANG Xin-hui SHEN Li-mei |
| Affiliation: | SUN Xian-guang1,XING Hui2,LI Zhi-jian1,HE Xiang2,ZHANG Xin-hui1,SHEN Li-mei1(1.Institute of Prevention and Control AIDS/STD/Dermatology of Guizhou Provincial CDC,Guiyang 550002,China,2.National Center for AIDS/STD of Chinese Center for Disease Prevention and Control,Beijing 102206,China) |
| Abstract: | Objective To study the effect of HIV-1 CRF01-AE strain and subtype in the transmission and epidemic to provid the scientific data for AIDS prevention and control.Methods One hundred and ninety HIV-1 strain samples from Guizhou province were tested in three periods.Env gene sequence was amplified and analyzed by Nested-PCR.Correlation analysis was done to the test results of AIDS and the epidemic situation in Guizhou province.Results The B,B,E and C subtypes,CRF07-BC,CRF08-BC and CRF01-AE of three subtypes o... |
| Keywords: | Genetic subtypes of HIV-1 strains Sexually transmitted AIDS epidemic |
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