绝经后2型糖尿病合并骨质疏松症患者外周血NLR、PLR、Cys-C水平与骨密度的相关性分析

目的研究绝经后2型糖尿病合并骨质疏松症(OP)患者外周血中性粒细胞淋巴细胞比值(NLR)、血小板淋巴细胞比值(PLR)、胱抑素C(Cys-C)水平与骨密度的相关性。方法回顾性选择2020年9月至2021年6月北京市大兴区医院内分泌及骨科门诊就诊的绝经后2型糖尿病患者192例,按照患者骨量情况分为骨量正常组、骨量减少组、OP组各64例。比较3组基线资料、外周血糖化血红蛋白(Hb A1c)、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、NLR、PLR、Cys-C等实验室指标与骨密度的水平。并分析L₁～L₄骨密度均值与各观察指标的相关性。结果骨量减少组、OP组患者年龄、绝经时间、糖尿病病程均高于骨量正常组,体重指数低于骨量正常组,差异均有统计学意义(P <0.05)。骨量减少组、OP组NLR、PLR、CysC均高于骨量正常组,且OP组NLR、PLR、Cys-C均高于骨量减少组,差异均有统计学意义(P <0.05)。骨量减少组、OP组腰椎L₁

Correlation analysis of NLR,PLR,Cys-C and bone mineral density in peripheral blood of postmenopausal type 2 diabetes mellitus patients with osteoporosis

Objective To investigate the correlation between the levels of neutrophil lymphocyte ratio(NLR),platelet lymphocyte ratio(PLR),Cystatin C(Cys-C)in peripheral blood and bone mineral density in postmenopausal type 2 diabetes mellitus patients with Osteoporosis(OP).Methods A total of 192 postmenopausal type 2 diabetes mellitus patients who attended the Department of Endocrinology and Orthopedics Outpatient,Daxing District Hospital from September 2020 to June 2021 were retrospectively selected.According to bone mass,the patients were divided into normal bone mass group,reduced bone mass group and OP group,64 cases in each group.Baseline data,peripheral hemoglobin A1c(HbA1c),fasting blood glucose(FBG),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),NLR,PLR,Cys-C and bone mineral density.And the correlation between the average value of L₁-L₄ bone mineral density and each observation index was analyzed.Results The age,menopausal time,and duration of diabetes in the reduced bone mass group and OP group were higher than those in the normal bone mass group,and the body mass index was lower than that in the normal bone mass group,the differences were statistically significant(P<0.05).NLR,PLR,and Cys-C in the reduced bone mass group and OP group were higher than those in the normal bone mass group,and NLR,PLR,and Cys-C in the OP group were higher than those in the reduced bone mass group,and the differences were statistically significant(P<0.05).The bone mineral density and the mean value of lumbar spine L₁-L₄ in the reduced bone mass group and the OP group were lower than those in the normal bone mass group,and the lumbar bone density and the mean value of the lumbar spine L₁-L₄ in the OP group were lower than those in the reduced bone mass group,and the differences were statistically significant.(P<0.05).Pearson correlation analysis showed that bone mineral density was not correlated with HbA1c,FBG,TC,TG,LDL-C and HDL-C(P>0.05),but it was positively correlated with body mass index(P<0.05),was negatively correlated with age,time of menopause,course of type 2 diabetes mellitus,NLR,PLR,Cys-C(P<0.05).Conclusion Bone mineral density of postmenopausal type 2 diabetes mellitus patients with OP was negatively correlated with age,menopause time,course of type 2 diabetes mellitus,NLR,PLR and Cys-C.Detection of NLR,PLR and Cys-C in peripheral blood was helpful to master bone mineral density of patients.