肥胖儿童哮喘临床特征及其对药物治疗反应性的研究

目的探讨肥胖儿童哮喘临床特征及其对药物治疗的反应性。方法选取2019年2月～2020年12月收治的儿童哮喘病例200例,进行回顾性分析。根据患儿体重指数(BMI)将其分为观察组与对照组。BMI≥28 kg/m²的100例患儿纳入观察组,BMI <28 kg/m²的100例患儿纳入对照组。两组患者均根据权威指南接受规范化吸入法治疗。对比两组患儿的临床特征以及治疗后的临床效果。结果对照组综合疗效总有效率为96.00%,观察组综合疗效总有效率为78.00%,两组相比,对照组综合疗效总有效率更高(P <0.05)。此外,两组患儿均未发生明显不良反应。治疗后,对照组患儿的IL-6和TNF-α水平均低于观察组患儿(P <0.05)。结论肥胖哮喘患儿的肺功能损害程度要大于正常体重的哮喘儿童。且在标准化治疗方案实施后,肥胖哮喘患儿的血清细胞因子指标不及正常体重哮喘患儿,这导致肥胖哮喘患儿的预后相对更差。临床上对于体重过大的哮喘患儿应足够重视,可考虑早期给予加强治疗,以改善患儿预后。

Clinical characteristics of asthma in obese children and its response to drug therapy

Objective To investigate the clinical characteristics of asthma in obese children and its response to drug therapy.Methods Retrospective analysis was performed on 200 children with asthma who were admitted from February 2019 to December 2020.The children were divided into observation group and control group according to body mass index(BMI).100 children with BMI≥28 kg/m² were included in the observation group,and 100 children with BMI<28 kg/m² were included in the control group.Patients in both groups received standardized inhalation according to authoritative guidelines.The clinical characteristics of the two groups of children and the clinical effect after treatment were compared.Results The total effective rate of the control group was 96.00%,and the total effective rate of the observation group was 78.00%.Compared with the two groups,the total effective rate of the control group was higher(P<0.05).In addition,no obvious adverse reactions occurred in the two groups.After treatment,the levels of IL-6 and TNF-αin the control group were lower than those in the observation group(P<0.05).Conclusion The degree of lung function impairment in obese asthmatic children is higher than that in normal asthmatic children.Moreover,after the implementation of standardized treatment,the serum cytokine indexes of obese children with asthma were lower than those of children with normal body mass asthma.This results in a relatively poor prognosis for obese children with asthma.Clinically,enough attention should be paid to obese children with asthma,and early intensive treatment can be considered to improve the prognosis of children.