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| 脑脊液生物标志物在阿尔茨海默病诊断中的价值 | |
| 引用本文： | 张晓敏,崔雨婷,张晶晶,王怡斐,王培昌. 脑脊液生物标志物在阿尔茨海默病诊断中的价值[J]. 中华检验医学杂志, 2022, 0(1): 8-13 |
| 作者姓名： | 张晓敏 崔雨婷 张晶晶 王怡斐 王培昌 |
| 作者单位： | 首都医科大学宣武医院检验科;首都医科大学临床检验诊断学系 |
| 基金项目： | 国家自然科学基金(82030064);2021年度“扬帆”计划重点医学专业(ZYLX202114);北京市临床重点专科(建设项目)。 |
| 摘 要： | 阿尔茨海默病（AD）是一种老年期的神经退行性疾病，早期干预是目前延缓该病进展的唯一可靠手段。该文汇总并分析近年来各类AD生物标志物研究的代表性文献，分类评述了各类脑脊液（GSF）标志物对AD诊断及鉴别诊断的效能。其中CSF Aβ42、Aβ42/Aβ40、tau蛋白、Aβ42/p-tau、生长相关蛋白43、突触相关蛋白2... |
| 关 键 词： | 脑脊液 生物标志物 阿尔茨海默病 |
Value of the biomarkers derived from cerebrospinal fluid in the diagnosis of Alzheimer disease |
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| Zhang Xiaomin,Cui Yuting,Zhang Jingjing,Wang Yifei,Wang Peichang. Value of the biomarkers derived from cerebrospinal fluid in the diagnosis of Alzheimer disease[J]. Chinese Journal of Laboratory Medicine, 2022, 0(1): 8-13 | |
| Authors: | Zhang Xiaomin Cui Yuting Zhang Jingjing Wang Yifei Wang Peichang |
| Affiliation: | (Clinical Laboratory of Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Department of Clinical Laboratory Diagnostics,Capital Medical University,Beijing 100069,China) |
| Abstract: | Alzheimer disease(AD)is a neurodegenerative disease in the elderly.Early intervention is the only reliable means to delay the progress of the disease.Referring to the diagnostic criteria of AD,this paper summarizes and analyzes the representative literatures of various AD biomarkers derived from cerebrospinal fluid in recent years,and reviews the efficacy of various cerebrospinal fluid biomarkers in the diagnosis and differential diagnosis of AD.Results show that CSF Aβ42,Aβ42/Aβ40,T-tau,p-tau,Aβ42/p-tau,growth-associated protein 43,synaptosomal-associated protein 25,neurogranin and visinin-like protein-1 are of great value in the diagnosis and differential diagnosis of AD.The above CSF biomarkers can be used in the diagnosis and differential diagnosis of AD.The laboratory should select appropriate AD CSF biomarkers according to its own conditions in daily laboratory works. |
| Keywords: | Cerebrospinal fluid Biomarker Alzheimer disease |
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