| DNA甲基转移酶在急性髓系白血病中作用的研究进展 |
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| 引用本文： | 姜慧慧,杨新,弭苗苗,辛钰,武洪远(综述),孙成铭(审校). DNA甲基转移酶在急性髓系白血病中作用的研究进展[J]. 国际检验医学杂志, 2022, 0(1) |
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| 作者姓名： | 姜慧慧 杨新 弭苗苗 辛钰 武洪远(综述) 孙成铭(审校) |
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| 作者单位： | 青岛大学医学部;青岛大学医学院附属烟台毓璜顶医院;滨州医学院 |
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| 基金项目： | 山东省重大科技创新工程项目(2019JZZY011018);山东省烟台市科技计划项目(2019MSGY133,2019YD004)。 |
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| 摘 要： | 急性髓系白血病(AML)的病因目前尚未完全阐明,研究发现其与异常的表观遗传学改变密切相关。DNA甲基化是由DNA甲基转移酶(DNMT)介导的表观遗传过程。DNMT由DNMT1、DNMT3A和DNMT3B组成,是高度保守的DNA修饰酶,其在表观遗传调控中发挥重要作用,并与AML的临床特征与治疗效果的关系十分密切。深入了解DNMT在AML中的作用,有助于阐明AML的发生机制,并为其临床治疗提供潜在的靶点。
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| 关 键 词： | 急性髓系白血病 表观遗传 DNA甲基化 DNA甲基转移酶 |
Research progress on the role of DNA methyltransferase in acute myeloid leukemia |
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| Affiliation: | (Department of Medicine,Qingdao University,Qingdao,Shandong 266000,China;Yantai Yuhuangding Hospital Affiliated to Qingdao University,Yantai,Shandong 264000,China;Binzhou Medical University,Yantai,Shandong 264000,China) |
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| Abstract: | The cause of acute myeloid leukemia(AML)has not yet been fully elucidated.Studies have found that it is closely related to abnormal epigenetic changes.DNA methylation is an epigenetic process mediated by DNA methyltransferase(DNMT).DNMT is composed of DNMT1,DNMT3A and DNMT3B.It is a highly conservative DNA modification enzyme that plays an important role in epigenetic regulation and is closely related to the clinical characteristics and therapeutic effects of AML.An in-depth understanding of the role of DNMT in AML will help clarify the mechanism of AML and provide potential targets for its clinical treatment. |
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| Keywords: | acute myeloid leukemia epigenetics DNA methylation DNA methyltransferase |
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