补肾益智汤治疗老年血管性痴呆的临床研究

目的观察补肾益智汤治疗老年血管性痴呆（肾虚髓减证）患者的临床疗效。方法将50例患者随机分为两组,每组各25例,治疗组采用补肾益智汤（组成：熟地、龟板、山药、黄精、山茱萸、茯苓、人参、丹皮、泽泻、牛脊髓）治疗;对照组采用甲磺酸双氢麦角碱片治疗。比较治疗2个月后治疗组与对照组Berg平衡量表积分的改善情况和脑电地形图的有效率。结果治疗2个月后,治疗组与对照组Berg平衡量表积分均有提高（P〈0.05）,两组Berg平衡量表积分比较差异有统计学意义（P〈0.05）;治疗组对脑电地形图有效率为68%,对照组对脑电地形图有效率为28%,两组对脑电地形图有效率比较,差异有统计学意义（P〈0.01）。治疗组疗效明显优于对照组。结论补肾益智汤治疗老年血管性痴呆肾虚髓减证有较好效果,值得临床推广应用。

Clinical Research of Senile Vascular Dementia Treated with Bushen Yizhi Decoction

Objective To observe the clinical efficacy of bushen yizhi decoction for the patients with senile vascular dementia(pattern/syndrome of kidney deficiency and marrow declining).Methods 50 cases were randomized into two groups,25 cases in each one.In a treatment group,bushen yizhi decoction(ingredients:radix rehmannia preparata,carapax et plastrum testudinis,disoscoprea opposita,rhizome polygonati,cornus officinalis,poria cocos,radix ginseng,cortex moutan,rhizome alismatis,cattle spinal cord)was prescribed.In a control group,co-dergocrine mesyiate tablets were prescribed.At the end of 2-month treatment,the improvements in Berg balance scale score and the effective rate of brain electric activity mapping(BEAM)were compared between the treatment group and the control group.Results At the end of 2-month treatment,the score of Berg balance scale was improved in both the treatment group and the control group(P<0.05).The difference in the improvement of Berg balance scale score was significant statistically in comparison between two groups(P<0.05).BEAM effective rate was 68% in the treatment group and was 28% in the control group,presenting the statistical significant difference(P<0.01).The efficacy in the treatment group was superior apparently to that in the control group.Conclusion Bushen yizhi decoction achieves the better effect on senile vascular dementia(pattern/syndrome of kidney deficiency and marrow declining)and deserves to be promoted in clinical application.