Disseminated Sporotrichosis in a Liver Transplant Patient: A Case Report |
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| Affiliation: | 1. Liver Transplantation Division, Federal District Institute of Cardiology, Brasília, Brazil;2. Medical School, Chatolic University of Brasilia, Brasília, Brazil;1. Laboratory of Immunology and Experimental Transplantation (LITEX), Medical School of Sao Jose do Rio Preto (FAMERP), SP, Brazil;2. Kidney Transplant Unit, Hospital de Base/FUNFARME, Sao Jose do Rio Preto, SP, Brazil;3. Urology and Nephrology Institute, Sao Jose Rio Preto, SP, Brazil;1. Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;2. Instituto Federal de Minas Gerais, Bambuí, Minas Gerais, Brazil;3. Prefeitura Municipal de Contagem, Contagem, Minas Gerais, Brazil;1. Department of Liver Transplantation, Federal District Institute of Cardiology, Instituto de Cardiologia do Distrito Federal, Brasília, Brazil;2. Medical School, Catholic University of Brasilia, Brasília, Brazil;1. São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, SP, Brazil;2. GC01 Immunology and Allergy Group. Maimonides Biomedical Research Institute of Cordoba (IMIBIC). Reina Sofía University Hospital, IMIBIC Building, Córdoba, Spain;3. Núcleo de Biotecnología Curauma (NBC), Pontificia Universidad Católica de Valparaíso, Campus Curauma, Valparaíso, Chile;4. São Carlos Institute of Chemistry, University of São Paulo, São Carlos, SP, P.O. Box 780, 13560–970, Brazil;5. Facultad de Ingeniería, Instituto de Ciencias Químicas Aplicadas, Universidad Autónoma de Chile, el Llano Subercaseaux 2801, San Miguel, Santiago, Chile;6. Grupo de Marcadores Inmunológicos, Laboratorio de Genética e Inmunología Molecular, Instituto de Biología, Pontificia Universidad Católica de Valparaíso, Avenida Universidad #330, 2373223, Valparaíso, Chile |
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| Abstract: | Sporotrichosis is an infection caused by the fungus of the Sporothrix schenckii complex and can be particularly harmful in immunocompromised patients. We report the case of a 26-year-old male patient with a previous history of pulmonary infection who underwent a liver transplant for Budd-Chiari syndrome. After the procedure, he presented with persistent fever and leukocytosis. On the 13th post-operative day, he was diagnosed with thrombosis of the hepatic artery and underwent a second liver transplant 15 days after the first procedure. After the retransplant, he presented daily episodes of fever, even after the use of several antimicrobial, antiviral, and antifungal agents. A number of negative cultures from different sites were obtained. After an acute episode of mental confusion, the growth of S schenckii was observed in cultures from cerebrospinal fluid and ascites obtained from a diagnostic paracentesis. Treatment with amphotericin B was started but the patient died on the fourth day of antifungal treatment, from a massive gastrointestinal hemorrhage. We found no previous report in the literature of spontaneous dissemination of S schenckii to the abdominal cavity causing peritonitis. |
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