Distribution of neuronal nitric oxide synthase immunoreactivity in adult male Sprague-Dawley rat brain |
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| Affiliation: | 1. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, PR China;2. Department of Biological Sciences, Sunway University, Selangor, Malaysia;3. Department of Neuroscience and European Graduate School of Neuroscience, Maastricht University, Maastricht, the Netherlands;1. Dept. Oral Pathology, Oral Medicine and Oral Radiology, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel;2. Institute of Pathology, The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel;1. Dept. Oral Pathology, Oral Medicine and Oral Radiology, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel;2. Institute of Pathology, The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel;3. Dept. Oral and Maxillofacial Surgery, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel;4. Cancer and Translational Research Unit, University of Oulu and MRC, Oulu University Hospital, Oulu, Finland;5. Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, and HUSLAB, Helsinki University Hospital, Helsinki, Finland;6. Dept. Oral and Maxillofacial Surgery, The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel;1. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region;2. Department of Physiology, Guangzhou University of Chinese Medicine, Guangdong, PR China;3. School of Biological Sciences, Nanyang Technological University, Singapore;4. Department of Biology, Clarkson University, Potsdam, New York, United States;1. Faculty of Biology Sciences, University of Sciences and Technology Houari Boumediene, Algeria;2. Immunology Service of Isaad Hassani-Beni Messous Hospital, Algiers, Algeria;3. Pathological Anatomy Service of Isaad Hassani-Beni Messous Hospital, Algiers, Algeria |
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| Abstract: | Neuronal NOS (nNOS) accounts for most of the NO production in the nervous system that modulates synaptic transmission and neuroplasticity. Although previous studies have selectively described the localisation of nNOS in specific brain regions, a comprehensive distribution profile of nNOS in the brain is lacking. Here we provided a detailed morphological characterization on the rostro-caudal distribution of neurons and fibres exhibiting positive nNOS-immunoreactivity in adult Sprague-Dawley rat brain. Our results demonstrated that neurons and fibres in the brain regions that exhibited high nNOS immunoreactivity include the olfactory-related areas, intermediate endopiriform nucleus, Islands of Calleja, subfornical organ, ventral lateral geniculate nucleus, parafascicular thalamic nucleus, superior colliculus, lateral terminal nucleus, pedunculopontine tegmental nucleus, periaqueductal gray, dorsal raphe nucleus, supragenual nucleus, nucleus of the trapezoid body, and the cerebellum. Moderate nNOS immunoreactivity was detected in the cerebral cortex, caudate putamen, hippocampus, thalamus, hypothalamus, amygdala, and the spinal cord. Finally, low NOS immunoreactivity were found in the corpus callosum, fornix, globus pallidus, anterior commissure, and the dorsal hippocampal commissure. In conclusion, this study provides a comprehensive view of the morphology and localisation of nNOS immunoreactivity in the brain that would contribute to a better understanding of the role played by nNOS in the brain. |
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| Keywords: | Neuronal nitric oxide synthase Immunohistochemistry Morphology Neuroanatomy |
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