Comparison of the Outcome of Kidney Transplant After Pulsatile or Continuous Ex Vivo Hypothermic Machine Perfusion of Kidneys Donated After Cardiac Death: Analysis of Kidney Pairs |
| |
| Affiliation: | 1. Nephrology Departmant, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey;2. Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne, United Kingdom;3. Department of Pharmacy Health and Well-Being, University of Sunderland, Sunderland, United Kingdom;4. School of Applied Sciences, University of Sunderland, Sunderland, United Kingdom;5. Renal Department, Freeman Hospital, Newcastle upon Tyne, United Kingdom;6. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom;1. Division of Urology, Department of Regenerative & Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan;2. Division of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan;3. Department of Pediatrics, Niigata University Medical and Dental Hospital, Niigata, Japan;4. Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan;1. Department of Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea;2. Division of Nephrology, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea;1. Department of Neurology, The University of Chicago, Chicago, IL 60637, USA;2. Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA;3. Advance Electron Microscopy Facility, Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA;4. Department of Anatomy, Histology, Embryology, University of Thessaly, Larissa, Greece;1. Liver Transplant Unit, Digestive and Metabolic Diseases Institute, Hospital Clínic, University of Barcelona, Barcelona, Spain;2. Transplant Coordination Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain;3. Pathology Department, Hospital Clínic, University of Barcelona, Barcelona, Spain;4. Barcelona-Clínic Liver Cancer Group (BCLC), Liver Unit, Institut d''Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBEREHD, Universitat de Barcelona, Barcelona, Catalonia, Spain |
| |
| Abstract: | BackgroundHypothermic machine perfusion is used to improve renal perfusion and reduce the rate of early and late graft dysfunction. It has been used in our unit since 2001. It has 2 modes of flow: continuous or pulsatile. The aim of this study is to compare the modes of perfusion in terms of perfusion-related parameters, graft survival, and estimated glomerular filtration rate.MethodsAll donation after cardiac death kidneys between 2002 and 2014 were reviewed. A total of 64 pairs of kidneys were identified of which one kidney underwent pulsatile and the other continuous perfusion. Machine parameters including resistance and perfusion flow index levels at 0, 1, 2, 3, and 4 hours were recorded and glutathione S-transferase was measured in perfusate. Estimated glomerular filtration rate from the first week of transplant until the fifth year and graft survival rates were determined.ResultsMachine parameters were similar at all time points. Estimated glomerular filtration rates and graft survival were the same irrespective of perfusion mode.ConclusionPulsatile perfusion may be regarded as more physiological. However, we could not identify difference in outcome following transplant of kidneys from the same donor that had been perfused under pulsatile or continuous conditions. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
