Survival Outcomes After Liver Transplantation in Elderly Patients: A Single-Center Retrospective Analysis |
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| Affiliation: | 1. Hepatopancreaticobiliary Surgery and Liver Transplantation Unit, Department of General Surgery, Dokuz Eylul University School of Medicine, Izmir, Turkey;2. Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey;3. Department of Preventive Oncology, Institute of Oncology, Dokuz Eylul University School of Medicine, Izmir, Turkey;1. Department of Surgery, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary;2. 2nd Department of Medicine and Cardiology Centre, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary;3. 1st Department of Medicine, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary;4. Department for Medical Translation and Communication, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary;1. Department of Organ Transplantation, Institute of Surgery, Faculty of Medicine, University of Debrecen, Debrecen, Hungary;2. Institute of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary;3. Laboratory of Immunogenetics, Hungarian National Blood Transfusion Service, Debrecen, Hungary;4. Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary;1. Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey;2. Organ Transplantation Center, Acibadem International Hospital, Istanbul, Turkey;1. Department of General Surgery, Kartal Training Hospital, Istanbul, Turkey;2. Department of Transplantation, Kartal Training Hospital, Istanbul, Turkey;3. Bahcesehir University, Department of General Surgery, Istanbul, Turkey;4. Department of Biochemistry, Yuzuncu Yil University, Van, Turkey;5. Department of Chest Diseases, Yeniyuzyil University, Istanbul, Turkey;6. Department of Nephrology, Tekirdag State Hospital, Tekirdag, Turkey;7. Bahcesehir University, Department of Nephrology, Istanbul, Turkey;1. Department of Pediatric Nephrology, Ege University Faculty of Medicine, İzmir, Turkey;2. Department of Nephrology, Ege University Faculty of Medicine, İzmir, Turkey;3. Department of Pathology, Ege University Faculty of Medicine, İzmir, Turkey;4. Department of General Surgery, Ege University Faculty of Medicine, İzmir, Turkey;1. Department of Nephrology, University of Health Sciences, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey;2. Department of Internal Medicine, Ege University Medical Faculty, İzmir, Turkey;3. Department of Pathology, Ege University Medical Faculty, İzmir, Turkey;4. Department of Nephrology, Ege University Medical Faculty, İzmir, Turkey;5. Department of Nephrology, Trakya University Medical Faculty, Edirne, Turkey |
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| Abstract: | AimThis study aims to evaluate survival rates in elderly patients after liver transplantation (LT) and to analyze the factors associated with mortality.Patients and methodsOur study includes 535 patients over the age of 18 who had undergone LT in our clinic between June 2004 and January 2018. Data were collected prospectively and scanned retrospectively. Data concerning the patients' age, sex, LT indication, Child-Turcotte-Pugh score, Model for End-Stage Liver Disease score, presence of hepatocellular cancer (HCC), coexisting disease, LT types, and post-transplant survival were investigated.The patients were grouped under 2 categories (18–59 years of age and 60 years of age and over) and were compared in terms of their characteristics. In patients aged 60 and over, the causes of mortality and related factors were investigated.ResultsThe study included 535 patients, 458 (85.6%) of whom were between 18 and 59 years of age and 77 (14.4%) were over 60 years of age. The median follow-up period was 86.7 (1 to 247) months. The elderly group's survival rate was significantly lower than that of the younger group (P = .002). In elderly patients, survival rates of 1, 3, 5, and 10 years were 67.4%, 56.4%, 53.8%, and 46.1%, respectively.ConclusionIn elderly patients, factors that increase post-LT mortality require thorough consideration. Equally important is the physiological status of the candidates for transplantation. Correct patient selection in the preoperative stage and good postoperative care can provide successful survival results in elderly patients. |
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