| 促红细胞生成素对慢性肾衰竭贫血患者骨髓超微结构的影响 |
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| 引用本文： | 王向杰,刘丽,刘键,周英杰,白玉,李巍,景晔,王国华,尹方秋.促红细胞生成素对慢性肾衰竭贫血患者骨髓超微结构的影响[J].华北国防医药,2011,23(6):3-5. |
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| 作者姓名： | 王向杰 刘丽 刘键 周英杰 白玉 李巍 景晔 王国华 尹方秋 |
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| 作者单位： | 1. 北京军区天津疗养院血透中心,天津,300381
2. 白求恩军医学院,石家庄,050081 |
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| 摘 要： | 目的 探讨促红细胞生成素(EPO)对慢性肾衰竭(CRF)贫血患者骨髓超微结构的影响.方法 对23例CRF贫血患者给予重组人红细胞生成素(rhEPO)100 U/kg,每周3次,并进行常规血液透析,于治疗前及治疗12周后检测血常规,观察骨髓超微结构改变情况.结果 治疗后血红蛋白、血细胞比容、网织红细胞和血小板较治疗前均升高(P＜0.05,P＜0.01);骨髓造血微环境恢复,三系各阶段血细胞超微结构恢复正常.结论 EPO是治疗CRF贫血的决定性生长因子.
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| 关 键 词： | 肾衰竭 慢性 贫血 促红细胞生成素 骨髓检查 |
Erythropoietin Effect on Marrow Hematopoietic Microenvironment of Chronic Renal Function Failure |
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| WANG Xiang-jie,LIU Li,LIU Jian,ZHOU Ying-jie,BAI Yu,LI Wei,JING Ye,WANG Guo-hua,YIN Fang-qiu.Erythropoietin Effect on Marrow Hematopoietic Microenvironment of Chronic Renal Function Failure[J].Medical Journal of Beijing Military Region,2011,23(6):3-5. |
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| Authors: | WANG Xiang-jie LIU Li LIU Jian ZHOU Ying-jie BAI Yu LI Wei JING Ye WANG Guo-hua YIN Fang-qiu |
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| Institution: | 1.Tianjin Sanatorium＇s Hemodialysis Center of Beijing Military Area Command,Tianjin 300381,China;2.Bethune Military Medical College,Shijiazhuang 050081,China) |
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| Abstract: | Objective To investigate erythropoietin affecting marrow hematopoietic microenvironment of patients with chronic renal function failure.Methods 23 CRF patients were given rhEPO injection（100 U/kg）,thrice per a week.All patients underwent regular hemodialysis.Blood routine test was conducted and marrow ultrastructure change was reviewed before and 12 weeks after treatment.Results After-treatment,peripheral blood hemoglobins,hematocrit,reticulocytes and platelet rose to（P0.05,P0.01）.Marrow hematopoietic microenvironment,as well as blood cells ultra-structure returned to normal.Conclusion Erythropoietin is a decisive growth factor in treatment of chronic renal function failure. |
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| Keywords: | Kidney failure chronic Anemia Erythropoietin Bone marrow examination |
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