| nm23/NDPK在前列腺癌中的表达及意义 |
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| 引用本文： | 臧晋,严春寅,张炜. nm23/NDPK在前列腺癌中的表达及意义[J]. 苏州大学学报(自然科学版), 2003, 23(5): 548-550 |
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| 作者姓名： | 臧晋 严春寅 张炜 |
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| 作者单位： | 苏州大学附属第一医院泌尿外科，苏州大学附属第一医院泌尿外科，苏州大学附属第一医院泌尿外科 苏州215006，苏州215006，导师，苏州215006 |
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| 摘 要： | 目的 研究nm2 3/NDPK在前列腺癌中表达的意义。方法 用免疫组织化学方法检测 4 0例前列腺癌标本中nm2 3/NDPK的表达情况。结果 在 4 0例前列腺癌标本中nm2 3/NDPK的阳性表达为 5 7.5 0 % (2 3/ 4 0 ) ,nm2 3/NDPK的表达随病理分化程度降低而下调 ;转移组 (36 .84 % )明显低于非转移组 (76 .19% ) ,P <0 .0 5。随前列腺癌Whitmore分期的增高 ,nm2 3/NDPK表达明显下调。结论 nm2 3基因在前列腺癌侵袭转移过程中发挥重要作用 ,检测nm2 3/NDPK的表达对评价前列腺癌的生物学行为和预测肿瘤进展有重要意义
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| 关 键 词： | 前列腺癌 nm23／NDPK 免疫组织化学 |
| 文章编号： | 1000-5749(2003)05-0548-03 |
| 修稿时间： | 2003-04-24 |
The Study of nm23/NDPK Expression in Human Prostate Cancer |
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| ZANG Jin,YAN Chun-yin,ZHANG Wei. The Study of nm23/NDPK Expression in Human Prostate Cancer[J]. Suzhou University Journal of Medical Science, 2003, 23(5): 548-550 |
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| Authors: | ZANG Jin YAN Chun-yin ZHANG Wei |
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| Abstract: | Objective To study the role of nm23/NDPK in carcinogenesis and metastasis of human prostate cancer. Methods The expression of nm23/NDPK was analyzed by means of immunohistochemistry in 40 patients with prostate cancer. Results Among 40 case 23(57.5%) had strongly positive expression of nm23/NDPK in the cytoplasm. The strongly positive expression of nm23/NDPK showed down-regulation following pathological stage progress and differentiation. Compared with the group of non-metastasis(76.19%), the positive expression of nm23/NDPK in the group of metastasis(36.84%) decreased significantly. Conclusion Measuring the expression of nm23 may be a great aid in evaluating the biological behavior of human prostate cancer and predicting tumor recurrence and progression. |
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| Keywords: | prostate cancer nm23/NDPK immunohistochemistry |
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