Ang-2与VEGF的协同作用及其在抗肿瘤血管新生治疗中的应用

肿瘤的血管生成是个复杂的过程,其中血管生成素（Ang）家族和血管内皮细胞生长因子（VEGF）家族协同作用至关重要。Ang家族是唯一含受体激动剂及抑制剂的促血管生成因子,均能与内皮细胞上的酪氨酸激酶受体Tie-2结合,参与血管生成。肿瘤细胞分泌VEGF,后者协同Ang-2促进血管的生成。对VEGF及Ang结构与作用机制的深入研究将有助于新的具有临床应用价值的抗血管生成药物的研制。本文就Ang及其受体的结构和作用机制,Ang及其受体在肿瘤血管新生治疗中的应用,以及Ang-2与VEGF的协同作用机制问题作一综述。

Synergism between Ang-2 and VEGF and Its Application of Anti-angiogenesis in Tumor Therapy——Review

Tumor angiogenesis is a complicated process in which VEGF and the members of Ang family have been proposed to play an important role. Ang family is the only vascular growth factor family including activators and inhibitors. They can all bind with specific tyrosine kinase receptor Tie-2 and participate in angiogenesis. Vascular endothelial growth factor (VEGF) is secreted by tumor cells and coordinates with Ang to promote angiogenesis. Further research on the structure and functional mechanism of VEGF and Ang will contribute to develop a new type of antiangiogenesis medicine, which might have good perspect in clinical practice. In this paper, the structure and action mechanism of Ang family and its receptor Tie-2, the application of Ang family and Tie in tumor therapy, and the synergic mechanism between Ang and VEGF were summarized.