Lens opacity in patients with hypercholesterolemia and ischaemic heart disease |
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Authors: | Markku Leino MD Kalevi Pyörälä Seppo Lehto Arto Rantala |
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Institution: | (1) Departments of Medicine and Ophthalmology, Kuopio University Hospital, Kuopio, Finland;(2) Viljelijantie 4/6, SF-70260 Kuopio, Finland |
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Abstract: | Lens opacity studies were performed using an electronic Lens Opacity Meter (Interzeag Opacity Lensmeter 701) in a population (n = 321) with ischaemic heart disease. These patients are participating in a trial targetting at the reduction of mortality and incidence of myocardial infarction using a cholesterol-lowering drug, simvastatin. A separate study to evaluate the reliability of the method showed good reproducibility. Repeated measurements after a short time-interval (2–10 days) gave statistically lower opacity values either due to a change in lens transparency or perhaps a change in pigment and cell dispersion in the acqueous caused by repeated mydriasis. Lens opacity values showed a highly significant positive correlation to age. Serum cholesterol, systolic blood pressure and smoking habits showed no significant correlations to the levels of lens opacity when adjustments for age were made.Abbreviations HMG-CoA
hydroxy-methylglutarylcoenzyme A
- 4S
Scandinavian Simvastatin Survival Study
- LOM
lens opacity meter |
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Keywords: | Blood pressure cataract cholesterol lens opacity meter opacity smoking |
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