| 甲氧基聚乙二醇-b-聚L-半胱氨酸两亲性嵌段共聚物的合成与表征 |
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| 引用本文： | 陈洋,肖艳. 甲氧基聚乙二醇-b-聚L-半胱氨酸两亲性嵌段共聚物的合成与表征[J]. 医学教育探索, 2016, 29(2): 188-192 |
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| 作者姓名： | 陈洋 肖艳 |
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| 作者单位： | 华东理工大学材料科学与工程学院, 上海 200237,华东理工大学材料科学与工程学院, 上海 200237 |
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| 摘 要： | 首先以聚乙二醇单甲醚(mPEG-OH)为单体,采用经典的盖布瑞尔伯胺合成法合成了端氨基聚乙二醇单甲醚(mPEG-NH2); 然后以mPEG-NH2为引发剂,S-苄基L-半胱氨酸N-羧酸内酸酐(BCys-NCA)为原料,通过N-羧酸内酸酐(NCA)开环聚合反应和液氨/钠处理脱除侧链上的保护基团,合成了两亲性嵌段共聚物甲氧基聚乙二醇-b-聚L-半胱氨酸(mPEG-b-PCys)。采用傅里叶变换红外光谱、核磁共振氢谱对聚合物的结构和组成进行了表征。结果表明:成功制备了侧链具有还原性巯基的两亲性嵌段共聚物mPEG-b-PCys,并且其聚合度可控性良好。
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| 关 键 词： | 聚乙二醇单甲醚 巯基 两亲性 嵌段共聚物 |
| 收稿时间： | 2016-05-08 |
Synthesis and Characterization of Poly(ethylene glycol)-b-Poly(L-cysteine) Block Copolymer |
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| CHEN Yang and XIAO Yan. Synthesis and Characterization of Poly(ethylene glycol)-b-Poly(L-cysteine) Block Copolymer[J]. Researches in Medical Education, 2016, 29(2): 188-192 |
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| Authors: | CHEN Yang and XIAO Yan |
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| Affiliation: | School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China and School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | Amine-terminated mPEG (mPEG-NH2) was first synthesized by Gabriel method using mPEG-OH as the monomer.Methoxy poly(ethylene glycol)-b-poly(L-cysteine) (mPEG-b-PCys) amphiphilic block copolymers were further synthesized by ring opening copolymerization of S-benzyl L-cysteine N-carboxyanhydride (BCys-NCA) initiated with the amine terminated mPEG and followed by the removal of the protected groups using liquid NH3/Na.The structures of the polymers were characterized by Nuclear Magnetic Resonance spectroscopy (1H-NMR) and Fourier Transform Infrared spectroscopy (FT-IR).Results showed that the amphiphilic block copolymers containing active thiol groups were synthesized successfully,and the degree of polymerization was controllable. |
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| Keywords: | poly(ethylene glycol) thiol group amphiphilic block copolymer |
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