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乳腺癌患者血清肿瘤标志物及细胞因子的临床意义
引用本文:孙昕,鲍扬漪,鲍键. 乳腺癌患者血清肿瘤标志物及细胞因子的临床意义[J]. 中国医药科学, 2011, 0(13): 17-20
作者姓名:孙昕  鲍扬漪  鲍键
作者单位:安徽医科大学第一附属医院
基金项目:安徽省2008年度高校省级自然科学研究项目(编号:KJ2008B36ZC)
摘    要:
目的探讨血清肿瘤标志物CEA、CA15-3、CA19-9、β-hCG及细胞因子TNF-α、IL-6检测在乳腺癌诊断中的价值。方法选取不同临床分期乳腺癌患者145例、乳腺癌良性肿瘤60例、正常对照50例,通过蛋白芯片法和酶联免疫吸附法测定各项指标浓度并进行比较。结果乳腺癌CEA、CA15-3、CA19-9、β-hCG及细胞因子TNF-α、IL-6的血清浓度均显著高于良性肿瘤组和正常对照组(P<0.01),且与肿瘤分期密切相关。结论 CEA、CA15-3、CA19-9、β-hCG及细胞因子TNF-α、IL-6均为乳腺癌重要的肿瘤标志物,其含量可能与乳腺癌的发生、发展有关,测定其含量可作为临床病情观察和监测疗效的辅助手段。

关 键 词:肿瘤标志物  血清  乳腺癌

The significance of detecting serum tumor markers and cytokines for patients with breast cancer
SUN Xin,BAO Yangyi,BAO Jian. The significance of detecting serum tumor markers and cytokines for patients with breast cancer[J]. China Medicine and Pharmacy, 2011, 0(13): 17-20
Authors:SUN Xin  BAO Yangyi  BAO Jian
Affiliation:The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China
Abstract:
Objective To study the clinical value of detecting serum levels of CEA,CA15-3,CA19-9,β-hCG and TNF-α,IL-6 for patients with breast carcinoma.Methods Using the protein chip and cheminescent immunoassay,we detected the serum levels of CEA,CA15-3,CA19-9,β-hCG and TNF-α,IL-6 in 145 patients with breast cancer,60 patients with benign breast tumors and 50 healthy control subjects.Results The serum levels of CEA,CA15-3,CA19-9,β-hCG and TNF-α,IL-6 in the breast cancer group were significantly higher than those in the benign breast disease group and the control group(P < 0.01).In the breast cancer group,the levels of these tumor markers were increased as the malignant degree increased and were remarkably higher in patients with metastasis.Conclusion CEA,CA15-3,CA19-9,β-hCG and TNF-α,IL-6 are important tumor markers of the breast cancer and the markers levels may associate with development of the breasr cancer.The determination of TNF-α and IL-6 levels in serum can help to obsevation of the breast cancer state as a assistant monitor methods.
Keywords:Tumor marker  Serum  Breasr cancer
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