Effect of interferon alpha,interferon beta,and interferon gamma on the in vitro growth of human renal adenocarcinoma cells |
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| Authors: | J Philip Kuebler Terry D Oberley Lorraine F Meisner Younan A Sidky Catherine A Reznikoff Ernest C Borden Kenneth B Cummings George T Bryan |
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| Institution: | (1) Department of Humart Oncology, University of Wisconsin Center for Health Sciences, 53792 Madison, Wisconsin, USA;(2) Department of Medicine/Oncology, University of Oklahoma Health Science Center, P.O. Box 26901, 73190 Oklahoma City, OK, USA;(3) Department of Pathology, University of Wisconsin Center for Health Sciences, 53792 Madison, Wisconsin, USA;(4) Department of Cytogenetics, University of Wisconsin Center for Health Sciences, 53792 Madison, Wisconsin, USA;(5) Department of Human Oncology, University of Wisconsin Center for Health Sciences, 53792 Madison, Wisconsin, USA;(6) Department of Human Oncology, University of Wisconsin Center for Health Sciences, 53792 Madison, Wisconsin, USA;(7) Department of Human Oncology, University of Wisconsin Center for Health Sciences, 53792 Madison, Wisconsin, USA;(8) Department of Urology, University of Wisconsin Center for Health Sciences, 53792 Madison, Wisconsin, USA;(9) Department of Human Oncology, University of Wisconsin Center for Health Sciences, 53792 Madison, Wisconsin, USA |
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| Abstract: | Interferon- , interferon- , and interferon- differ in their antiproliferative effects for several cell lines. Interferons were thus assessed for their activity in inhibiting proliferation of three renal cell carcinoma cell lines. The malignant epithelial phenotype of each of these cell lines was confirmed by electron microscopy, histology, karyotype and tumorigenicity. When compared on an anti-viral unit basis, naturally produced interferon- was more effective than natural interferon- for all cell lines and clones. Proliferation of each of the cell lines was inhibited by interferon-. In all cases, removal of interferons from culture media resulted in resumption of the rate of cell growth after a variable delay of 6–10 days. If the antiproliferative effects of interferons predominate in mediating tumor regression, clinical response may depend upon the type of interferon to which the tumor is exposed. |
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| Keywords: | interferon antiproliferation renal cell lines |
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