| IL-25和IL-33促进Th2细胞分化的研究进展 |
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| 引用本文： | 徐燕全,吴长有. IL-25和IL-33促进Th2细胞分化的研究进展[J]. 国际免疫学杂志, 2010, 33(6): 417-419. DOI: 10.3760/cma.j.issn.1673-4394.2010.06.001 |
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| 作者姓名： | 徐燕全 吴长有 |
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| 作者单位： | 510080,广州,中山大学中山医学院免疫学教研室;热带病防治研究教育部重点实验室;510080,广州,中山大学中山医学院免疫学教研室;热带病防治研究教育部重点实验室 |
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| 摘 要： | Th2细胞介导的免疫应答是机体清除寄生虫感染和变态反应性疾病发生的主要机制。T细胞产生的一些细胞因子能够有效地调节和促进Th2细胞介导的免疫应答。最近的研究发现,肠粘膜上皮细胞分泌的IL-25和IL-33可以诱导几种新型的固有免疫细胞来促进Th2细胞的分化和激活,增加IL4、IL-5和IL—13的分泌,从而清除体内寄生虫。
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| 关 键 词： | Th2细胞 免疫应答 IL-25 IL-33 |
Research advances in how Th2 cells are initiated by IL-25 and IL-33 |
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| XU Yan-quan,WU Chang-you. Research advances in how Th2 cells are initiated by IL-25 and IL-33[J]. International Journal of Immunology, 2010, 33(6): 417-419. DOI: 10.3760/cma.j.issn.1673-4394.2010.06.001 |
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| Authors: | XU Yan-quan WU Chang-you |
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| Affiliation: | .( Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China) |
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| Abstract: | Th2 cells control immunity to extracellular parasites and allergic inflammatory responses.Th2 mediated immune responses are regulated and amplified by some T cell-associated cytokines. Recent studies showed that intestinal epithelial cell-derived IL-25 and IL-33 can induce three types of innate immune cells to initiate and activate Th2 cells to release IL-4, IL-5 and IL-13, which then induce immunity against the parasites. |
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| Keywords: | IL-25 IL-33 |
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