| 奥沙利铂联合吉西他滨治疗晚期胰腺癌的临床观察 |
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| 引用本文： | 马蕾,柳江.奥沙利铂联合吉西他滨治疗晚期胰腺癌的临床观察[J].临床肿瘤学杂志,2006,11(10):781-782,784. |
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| 作者姓名： | 马蕾 柳江 |
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| 作者单位： | 830001,乌鲁木齐,新疆维吾尔自治区人民医院肿瘤内科 |
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| 摘 要： | 目的:观察奥沙利铂联合吉西他滨治疗晚期胰腺癌的疗效及不良反应。方法:经影像学诊断的晚期胰腺癌18例,使用奥沙利铂85mg/m2,静脉滴注2小时,第1、8天;吉西他滨835mg/m2,静脉滴注30分钟,第1、8天,21天为1周期,至少用2周期后评价疗效。结果:18例均可评价,获得CR1例,PR3例,总有效率22·2%(4/18)。主要不良反应为骨髓抑制、外周神经毒性及恶心呕吐,无化疗相关死亡。结论:奥沙利铂联合吉西他滨治疗晚期胰腺癌患者疗效较好,不良反应可以耐受,值得深入研究。
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| 关 键 词： | 胰腺癌 奥沙利铂 吉西他滨 |
| 文章编号： | 1009-0460（2006）10-0781-03 |
| 收稿时间： | 2006-04-01 |
| 修稿时间： | 2006-06-18 |
Clinical observation of oxaliplatin plus gemcitabine for 18 patients with advanced pancreatic cancer |
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| MA Lei,LIU Jiang.Clinical observation of oxaliplatin plus gemcitabine for 18 patients with advanced pancreatic cancer[J].Chinese Clinical Oncology,2006,11(10):781-782,784. |
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| Authors: | MA Lei LIU Jiang |
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| Abstract: | Objective:To evaluate the clinical effect and toxicity of oxaliplatin plus gemcitabine in the treatment of advanced pancreatic cancer.Methods:18 patients with advanced pancreatic cancer diagnosed by imageology were treated with oxaliplatin 85mg/m~2 2 hours iv and gemcitabine 835mg/m~2 30 minutes iv on d1,d8.The regimen was repeated every 21 days and at least two cycles.The evaluation was performed after two cycles. Results:18 patients had evaluative lesions. CR was observed in 1 case and PR in 3 cases,the total response rate was 22.2%(4/18).The main side effects were myelosuppression, neuro-sensory toxicity and nausea/vomiting. There was no any death events during the treatment. Conclusion:oxaliplatin plus gemcitabine in the treatment of advanced pancreatic cancer is effective and tolerable.It is worth studying in future. |
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| Keywords: | Pancreatic cancer Oxaliplatin Gemcitabine |
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