| 拉曼光谱快速检测盐酸左氧氟沙星注射液 |
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| 引用本文： | 陈斌,张少敏,余岳林,陈桂良,乐健,张予敏.拉曼光谱快速检测盐酸左氧氟沙星注射液[J].药物分析杂志,2011(9). |
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| 作者姓名： | 陈斌 张少敏 余岳林 陈桂良 乐健 张予敏 |
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| 作者单位： | 上海市闸北食品药品检验所;上海市食品药品检验所;上海市食品药品监督管理局; |
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| 基金项目： | 上海市食品药品监督管理局十二五规划子课题(编号:2011JY1-5) |
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| 摘 要： | 目的:建立一种运用拉曼光谱技术快速鉴别、检查和测定盐酸左氧氟沙星注射液的方法。方法:以氧氟沙星、左氧氟沙星、盐酸左氧氟沙星以及盐酸左氧氟沙星注射液为研究对象,运用拉曼光谱技术对盐酸左氧氟沙星注射液进行快速鉴别、检查和含量测定。结果:拉曼光谱法可以鉴别出氧氟沙星消旋体和左氧氟沙星,辨别出不同pH的左氧氟沙星注射液的图谱差异并可用于盐酸左氧氟沙星注射液的含量测定。结论:本方法操作简便、快速无损,可成为注射剂快速检测的分析方法。
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| 关 键 词： | 拉曼光谱 快速检测 左氧氟沙星 氧氟沙星 消旋体 鉴别 |
Rapid Raman spectra identification and determination of levofloxacin hydrochloride injection |
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| CHEN Bin,ZHANG Shao-min,YU Yue-lin,CHEN Gui-liang,LE Jian,ZHANG Yu-min.Rapid Raman spectra identification and determination of levofloxacin hydrochloride injection[J].Chinese Journal of Pharmaceutical Analysis,2011(9). |
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| Authors: | CHEN Bin ZHANG Shao-min YU Yue-lin CHEN Gui-liang LE Jian ZHANG Yu-min |
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| Institution: | CHEN Bin1,ZHANG Shao-min1,YU Yue-lin1,CHEN Gui-liang2,LE Jian2,ZHANG Yu-min3(1.Shanghai Zhabei Institute for Food and Drug Control,Shanghai 200435,China,2.Shanghai Institute for Food and Drug Control,Shanghai 201203,3.Shanghai Municipality Food and Drug Administration,Shanghai 200010,China) |
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| Abstract: | Objective:To develop a method for the rapid identification,test and determination of levofloxacin hydrochloride injection using Raman spectra.Method:Raman spectra was used as the method of identifying,testing and determination the levofloxacin hydrochloride injection.Results:The result showed that the method of Raman spectra can identify the different of floxacin(despinner),levofloxacin and levofloxacin hydrochloride,test pH of levofloxacin hydrochloride injection,determinate the levofloxacin hydrochloride ... |
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| Keywords: | Raman spectra rapid identification and etermination levofloxacin ofloxacin despinner identification |
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