| 基于高生物利用度的创新组分结构中药制剂技术研究 |
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| 引用本文： | 侯雪峰,汪刚,邱辉辉,封亮,贾晓斌.基于高生物利用度的创新组分结构中药制剂技术研究[J].中草药,2017,48(16):3280-3287. |
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| 作者姓名： | 侯雪峰 汪刚 邱辉辉 封亮 贾晓斌 |
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| 作者单位： | 江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;安徽中医药大学, 安徽 合肥 230012;上海中医药大学, 上海 201203;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;安徽中医药大学, 安徽 合肥 230012;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028 |
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| 基金项目： | 国家自然科学基金资助项目（81573620）;江苏省“六大人才高峰”创新团队“组分结构创新中药基础研究与应用”（SWYY-CXTD-004）;江苏省科教强卫工程创新团队“中药组分性质表征与组分制剂技术”（CXTDB201700）;江苏省青年医学人才项目（QNRC2016634） |
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| 摘 要： | 中药制剂现代化是目前中药发展进程中的主要方向,而中药是一个具有多组分、多途径、多靶点整体作用特点的复杂体系,存在着物质基础尚不明确、作用机制不清晰等问题,这些都制约着中药制剂现代化的发展。加强中药组分的理论探索,提高组分制剂技术水平,促进中药组分制剂的发展,对实现中药现代化具有重要的意义。以"组分结构"理论为指导,从原材料前处理工艺和制剂成型技术2个方面系统阐述,以提出高组分生物利用度为目的,论述创新组分结构中药制剂的研究思路。
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| 关 键 词： | 创新组分结构中药制剂 组分结构 制剂技术 生物利用度 组分生物药剂学分类系统 |
| 收稿时间： | 2017/7/18 0:00:00 |
Study on technology of innovative component structure in Chinese materia medica preparation based on enhanced bioavailability |
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| HOU Xue-feng,WANG Gang,QIU Hui-hui,FENG Liang and JIA Xiao-bin.Study on technology of innovative component structure in Chinese materia medica preparation based on enhanced bioavailability[J].Chinese Traditional and Herbal Drugs,2017,48(16):3280-3287. |
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| Authors: | HOU Xue-feng WANG Gang QIU Hui-hui FENG Liang and JIA Xiao-bin |
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| Institution: | Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Anhui University of Chinese Medicine, Hefei 230012, China;Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Anhui University of Chinese Medicine, Hefei 230012, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China |
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| Abstract: | Modernization of Chinese materia medica (CMM) is the main direction of development of CMM. As a complex system, CMM has the whole characteristics with multi-component, multi-channel and multi-target. However, the lack of material base of CMM and the unknown mechanism of action restrict the development of modern medicine. Strengthening the theoretical exploration of Chinese medicine components, which could improve the technical level of component preparation and promote the development of CMM component preparation, is the key to realize the modernization of CMM. This paper reviews the preparation technology of CMM component combined with components of biological pharmacy classification system for the purpose of improving the bioavailability of components based on the "component structure" theory. |
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| Keywords: | innovative structural components of Chinese materia medica preparation component structure preparation technology bioavailability construction of components biopharmaceutical classification system |
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