索利那新和奥昔布宁治疗老年经尿道前列腺电切术后膀胱痉挛的比较研究

目的比较索利那新和奥昔布宁治疗老年经尿道前列腺电切术后膀胱痉挛的临床疗效。方法选取2016年2月—2017年2月在儋州市人民医院治疗的老年经尿道前列腺电切术后膀胱痉挛患者90例,按照治疗方法的不同分为对照组(45例)和治疗组(45例)。对照组口服盐酸奥昔布宁片,5 mg/次,2次/d。治疗组口服琥珀酸索利那新片,5 mg/次,2次/d。所有患者均在拔出尿管后3 d停药。评价两组患者临床疗效,同时比较治疗前后两组患者膀胱痉挛次数和持续时间,尿频和尿急次数,OABSS和PPBC评分。结果治疗后,对照组和治疗组总有效率分别为82.22%、97.78%,两组比较差异具有统计学意义(P0.05)。治疗2、3 d后,治疗组膀胱痉挛次数和持续时间均明显少于对照组(P0.05)。治疗1、3 d后,治疗组患者尿频、尿急次数均显著少于对照组(P0.05)。治疗后,两组OABSS和PPBC评分均明显下降(P0.05);且治疗组患者OABSS和PPBC评分明显低于对照组(P0.05)。结论索利那新治疗老年经尿道前列腺电切术后膀胱痉挛效果显著,可有效改善患者临床症状,具有一定的临床推广应用价值。

Comparison on solifenacin and oxybutynin in treatment of senile bladder spasm after transurethral resection of prostate

Objective To compare the clinical efficacy of solifenacin and oxybutynin in treatment of senile bladder spasm after transurethral resection of prostate. Methods Patients (90 cases) with bladder spasm after transurethral resection of prostate in Danzhou People''s Hospital from February 2016 to February 2017 were divided into control (45 cases) and treatment (45 cases) groups based on different treatment. Patients in the control group were po administered with Oxybutynin Hydrochloride Tablets, 5 mg/time, twice daily. Patients in the treatment group were po administered with Solifenacin Succinate Tablets, 5 mg/time, twice daily. Patients in two groups were withdrew after pulling out the catheter for 3 d. After treatment, clinical efficacy was evaluated, and the frequency and duration of bladder spasm, the frequency of micturition and urgency, OABSS and PPBC scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 82.22% and 97.78%, respectively, and there were differences between two groups (P<0.05). After treatment for 2 and 3 d, the frequency and duration of bladder spasm in the treatment group were significantly less than patients in the control group (P<0.05). After treatment for 1 and 3 d, the frequency of micturition and urgency in the treatment group were significantly less than patients in the control group (P<0.05). After treatment, the OABSS and PPBC scores in two groups were significantly decreased (P<0.05). And the OABSS and PPBC scores in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Solifenacin and oxybutynin has significant efficacy in treatment of senile bladder spasm after transurethral resection of prostate, can effectively improve the clinical symptoms, which has a certain clinical application value.