不同剂量左甲状腺素治疗老年亚临床甲状腺功能减退症疗效评价及对血脂的影响

目的 探讨不同剂量左甲状腺素治疗老年亚临床甲状腺功能减退症的临床疗效及对血压的影响。方法 以2013年3月-2016年5月于旬阳县医院就诊的老年亚临床甲状腺功能减退症患者98例作为研究对象，平均分为A、B两组各49例，两组患者均使用左甲状腺素进行治疗。A组患者初始剂量为12.5 μg/d，B组患者初始剂量为25 μg/d，每两周增加剂量25 μg/d，维持剂量50~150 μg/d治疗12周。比较两组患者临床疗效、甲状腺功能、血脂水平以及不良反应。结果 A组患者治愈率与总有效率分别为59.18%与87.76%，B组患者治愈率与总有效率分别为61.22%与91.84%，两组患者临床疗效差异不显著。治疗后两组患者甲状腺功能及血脂水平均优于治疗前，差异有统计学意义（P<0.05）。治疗4周后，B组患者甲状腺功能及血脂水平优于A组，差异有统计学意义（P<0.05）；治疗12周后，两组患者甲状腺功能及血脂水平差异不显著。A组总不良反应发生率为4.08%，明显低于B组的16.33%，差异有统计学意义（P<0.05）。结论 不同剂量左甲状腺素治疗老年亚临床甲状腺功能减退症疗效相当，大剂量组短期内改善甲状腺功能及血脂效果更好，但低剂量左甲状腺素不良反应较少，临床应根据患者情况采用合适剂量治疗。

Efficacy of different doses of levothyroxinein treatment of subclinical hypothyroidism in elderly patients and the effect on blood lipid level

Objective To investigate the clinical effect of different doses of levothyroxine in treatment of subclinical hypothyroidism and its effect on blood lipid level. Methods 98 cases of subclinical hypothyroidism elderly patients accepted in our hospital from March 2013 to May 2016 were divided into group A and B with 49 patients in each. The two groups were treated with different doses of levothyroxine treatment for 6 months. Then the clinical efficacy, thyroid function, blood lipid levels and adverse reactions of two groups were compared. Results The cure rate and total effective rate of group A were 59.18% and 87.76% respectively. The cure rate and total effective rate of group B were 61.22% and 91.84% respectively. There was no significant differencebetween two groups. After treatment, thethyroid function and blood lipid levels of two groups were better than before treatment. After 4 weeks of treatment, the thyroid function and blood lipid level in group B were better than those in group A (P<0.05). There was no significant difference in thyroid function and blood lipid between the two groups after 12 weeks of treatment. The incidence of total adverse reactions in group A was 4.08%, which was significantly lower than that in group B (16.33%), the difference was statistically significant (P<0.05). Conclusion Different doses of levothyroxine in the treatment ofsubclinical hypothyroidism were similar, and the thyroid function and blood lipids levels were improved after treatment, but the adverse reaction rate of low dose group was less.