脑心通胶囊联合卡维地洛治疗原发性高血压的疗效观察

目的观察脑心通胶囊联合卡维地洛治疗原发性高血压的临床疗效。方法选取2016年1月—2017年1月北京恒和中西医结合医院收治初诊的120例原发性高血压患者,随机分为对照组和治疗组,每组各60例。对照组患者口服卡维地洛胶囊,1粒/次,第1周1次/d,第2周增至2次/d,之后酌情增减用量,原则上不超过4次/d。治疗组在对照组治疗基础上口服脑心通胶囊,2粒/次,3次/d。两组患者均连续治疗1个月。观察两组的临床疗效,比较两组治疗前后收缩压、舒张压、SAS评分、SDS评分、生活自理能力评分的变化情况。结果治疗后,对照组和治疗组的总有效率分别为73.33%、91.67%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者收缩压、舒张压、SAS评分、SDS评分均较治疗前显著降低,生活自理能力评分显著升高,同组治疗前后差异有统计学意义(P0.05);治疗后,治疗组收缩压、舒张压、SAS评分、SDS评分低于对照组,生活自理能力评分高于对照组,两组比较差异具有统计学意义(P0.05)。结论脑心通胶囊联合卡维地洛治疗原发性高血压具有明显的临床疗效,可显著降低患者收缩压和舒张压,提高患者生活自理能力评分,具有一定的临床推广应用价值。

Clinical observation on Naoxintong Capsules combined with carvedilol in treatment of primary hypertension

Objective To observe the curative effect of Naoxintong capsules combined with carvedilol in treatment of primary hypertension. Methods Patients (120 cases) with primary hypertension in Beijing Henghe Hospital of Integrated Traditional Chinese and Western Medicine from January 2016 to January 2017 were randomly divided into control (60 cases) and treatment (60 cases) groups. Patients in the control group were po administered with Carvedilol Capsules, 1 grain/time, once daily on the first week, twice daily on the second week. After that, the dosage should be increased as appropriate, but the dosage was no more than 4 times/d in principle. Patients in the treatment group were po administered with Naoxintong Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacy was evaluated, and the changes of systolic pressure, diastolic blood pressure, SAS score, SDS score, and life self-evaluation ability score in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 73.33% and 91.67%, respectively, and there was difference between two groups (P<0.05). After treatment, systolic pressure, diastolic blood pressure, SAS score, and SDS score in two groups significantly decreased, but life self-evaluation ability score obviously increased, and the difference was statistically significant in the same group (P<0.05). After treatment, systolic pressure, diastolic blood pressure, SAS score, and SDS score in treatment group were lower than those in the control group, but life self-evaluation ability score was higher than that in the control group, and there was difference between two groups (P<0.05). Conclusion Naoxintong Capsules combined with carvedilol has good clinical effect in treatment of primary hypertension, can significantly reduce systolic pressure and diastolic pressure in patients, and can improve life self-evaluation ability score, which has a certain clinical application value.