Clinical epidemiology of ciprofloxacin-resistant Proteus mirabilis isolated from urine samples of hospitalised patients |
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| Authors: | R. Saito S. Okugawa W. Kumita K. Sato T. Chida N. Okamura K. Moriya K. Koike |
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| Affiliation: | Department of Infection Control and Prevention, The University of Tokyo Hospital, Tokyo, Japan. saito-lab@h.u-tokyo.ac.jp |
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| Abstract: | ![]()
This study investigated the clinical characteristics of ciprofloxacin-resistant Proteus mirabilis isolates from urine samples associated with nosocomial infection or colonisation, and identified the risk-factors for ciprofloxacin resistance. Data for patients with ciprofloxacin-resistant P. mirabilis isolates (n=13) were compared with those for randomly selected patients with ciprofloxacin-susceptible P. mirabilis isolates (n=40) who were matched by temporal occurrence as control patients. The majority of ciprofloxacin-resistant P. mirabilis isolates were multiresistant, and ciprofloxacin resistance was associated significantly with previous use of fluoroquinolones and production of extended-spectrum beta-lactamases. |
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| Keywords: | Epidemiology extended-spectrum β-lactamases fluoroquinolones Proteus mirabilis risk-factors urinary tract infection |
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