| 布洛芬分散片的制剂工艺研究 |
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| 引用本文： | 李志,郭新红,张振中,陈楠.布洛芬分散片的制剂工艺研究[J].郑州大学学报(医学版),2002,37(1):58-60. |
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| 作者姓名： | 李志 郭新红 张振中 陈楠 |
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| 作者单位： | 郑州大学药学系,郑州,450052 |
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| 摘 要： | 目的：布洛芬分散片处方筛选并对优选处方崩解度，分散性均匀性及体外溶出度进行实验，方法：用正交设计法，崩解剂，粘合剂，辅助粘合剂的各类及配比为因素，在3个水平上拟合，以崩解时限为指标用L9（3^3）进行实验。结果：优选处方中崩解剂为CMS－Na60g/L，辅助崩解剂MCC150g/L，粘合剂为10g/L PVP（300g/L乙醇水溶液）。结论；按最优处方组成制备分散片均在50s内完全崩解，分散均匀性达到中国药典（2000年版）关于分散片的要求。体外溶出度明显优于普通片。
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| 关 键 词： | 布洛芬 分散片 正交设计 |
| 修稿时间： | 2001年6月22日 |
Study on formulation of ibuprofen dispersible tablets |
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| LI Zhi,GUO Xinhong,ZHANG Zhenzhong,CHEN Nan.Study on formulation of ibuprofen dispersible tablets[J].Journal of Zhengzhou University: Med Sci,2002,37(1):58-60. |
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| Authors: | LI Zhi GUO Xinhong ZHANG Zhenzhong CHEN Nan |
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| Institution: | LI Zhi,GUO Xinhong,ZHANG Zhenzhong,CHEN Nan Department of Pharmacology,Zhenzhou University,Zhenzhou 450052 |
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| Abstract: | Aim: To select formulation for ibuprofen dispersible tablets and to evaluate the optimum dispersible tablets by disintegration and dissolution. Methods: Experiments were conducted by orthogonal design and disintegrants, adhesives and assistant adhesives were used as influencing factors and table L9(33) was used. Results: The optimum dispersible tablet compositions were: CMS-Na 60 g/L,MCC 50 g/L and PVP 10 g/L(300 g/L ethanol solution). Conclusion: The preparation complies with the requirement of Chinese Pharmacopoeia 2000. |
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| Keywords: | ibuprofen dispersible tablet orthogonal design method |
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