Oral anticoagulant therapy: practical considerations.

The key to safe and effective oral anticoagulation is to have an understanding of the rationale for dosing guidelines and therapeutic ranges; an appreciation of the imprecision of prothrombin time testing and its standardization; knowledge of the factors influencing prothrombin time response; and awareness of the importance of patient empowerment via ongoing patient education. This review focuses on the routine management of oral anticoagulant therapy to provide these practical insights and to promote safe and effective therapy.