Hypothalamic digoxin,cerebral dominance,and Golgi body/lysosomal function

The present study assessed the biochemical differences of glycoconjugate metabolism between right hemispheric dominant and left hemispheric dominant individuals. The isoprenoid metabolites--digoxin and dolichol, glycoconjugates, and lysosomal enzymes--were studied. The results showed that right hemispheric dominant individuals had increased (i) HMG CoA reductase activity and elevated digoxin levels, and (ii) increased dolichol and glycoconjugate levels with reduced lysosomal stability. Left hemispheric dominant individuals had the opposite patterns. Right hemispheric dominance represents a hyperdigoxinemic state with membrane sodium-potassium ATPase inhibition. Left hemispheric dominance represents the reverse pattern with hypodigoxinemia and membrane sodium-potassium ATPase stimulation. Cerebral dominance can regulate glycoconjugate metabolism (golgi body/lysosomal function).